Researchers have published a new technique for the rapid and accurate identification of fentanyl, as well as a vast number of other drugs of abuse.
We talk to Zheng Oyang about his career, emerging technologies and miniature mass spectrometry as a focus for his recent work.
Post-acquisition data mining techniques for LC–MS/MS-acquired data in drug metabolite identification
This review discusses the targeted and untargeted post-acquisition data mining techniques, which facilitate the drug metabolite identification. Learn more in this article from Bioanalysis.
Live event: Tuesday 5 November 2017 at 7:00 [PST] 10:00 [EST] 15:00 [GMT].
A targeted, sensitive, robust, reliable and cost-effective workflow for quantitation of biologics
Development of Native and Denaturing LC-MS Methods for Characterization of Cysteine-Linked Antibody Drug Conjugates Using a Non-Toxic Mimic
Here we utilize a cysteine-linked antibody fluorophore conjugate to show how LC-MS methods may be optimized using a non-toxic ADC-mimic. The ADC-mimic was used to develop native and reduced SEC-MS conditions. The reduced mimic’s heavy and light chains, as well as its IdeS-proteolysis fragments, were used to develop reversed-phase LC-MS methods. A tryptic digest of the ADC mimic was used to develop a peptide mapping LC-MS method.
Biocompatible Solid Phase Micro Extraction (BioSPME): A Tool to Overcome Matrix Effect for Multi-Class Compound Methods
Biocompatible solid phase micro extraction (BioSPME) is a sample preparation method that allows for the extraction of various analytes of interest from complex biological matrices without significant co-extraction of common interferences including salts, proteins, and phospholipids. Analytes can be recovered by simply desorbing within an organic solvent prior to analysis. Significant reduction in matrix interferences allows the user to focus on the separation of analytes during method development.
Thermo Fisher Scientific announce technology updates and additional features to their high-resolution accurate mass GC–MS systems
Enhancements to the high-resolution accurate mass GC–MS systems, from Thermo Fisher Scientific, have allowed higher levels of accuracy in data collection.
Parallelism experiments to evaluate matrix effects, selectivity and sensitivity in ligand-binding assay method development: pros and cons
This review compares and discusses all available approaches that can be used to assess key assay parameters for pharmacokinetic and biomarker ligand-binding assays. Find out more in this article from Bioanalysis.
Integrating Ion Mobility into Routine Metabolite Identification Studies Using the Vion IMS QTof Mass Spectrometer
This application note outlines and focuses on the benefits and the ease of use of ion mobility for the application of metabolite identification.
Q&A follow up: Moving from small molecule to large molecule bioanalysis by LC–MS/MS: A case study on challenges and techniques
Bioanalysis Zone hosted a free online webinar, ‘Moving from small molecule to large molecule bioanalysis by LC–MS/MS: A case study on challenges and techniques.’ Here, the speakers answer questions from the audience which we did not get a chance to answer during the webinar.