Electron paramagnetic resonance has been used to measure in-cell distances between spin labels with higher sensitivity than previously seen for conversional methods.
We look at some of the highlights of our Twitter chat (#TalkProteomics), where we questioned panelists John Wilson, Ben Orsburn, Matthias Trost and Eduardo Chicano Gálvez about all things proteomics – from mass spectrometry to drug discovery.
This editorial provides an insight into the advancing field of microsampling as a tool to monitor critically ill patients in the clinic, highlighting the need for further development to ensure patients receive the highest quality of care.
In this Bioanalysis Zone interview, Pegah Jalili (MilliporeSigma) discusses her current work in analytical R&D of biotherapeutic characterization and quantification, and what she thinks the future looks like for this field of bioanalysis.
An author’s perspective: Zhengqi Ye on approaches to measure protein binding of enzymatically unstable compounds
We talk to Zhengqi Ye about the approaches she uses to measure protein binding of enzymatically unstable compounds in plasma in this interview as part of our author’s perspective series.
We talk to Laura Rowe about her work using UHPLC to analyse protein glycosylation in this interview as part of our author’s perspective series.
This review article from Bioanalysis> introduces the differences between UHPLC and HPLC, and reviews the use of UHPLC in the last 5 years when studying the glycosylation of proteins and glycoprofiling biopharmaceuticals.
In this interview, Laura Mercolini (University of Bologna) discusses the advantages and disadvantages of using volumetric absorptive microsampling (VAMS) as a bioanalytical tool, touching upon her recent paper on the same topic.
An author’s perspective: Wenying Jian on bioanalytical workflow for novel scaffold protein–drug conjugates
We talk to Wenying Jian about her work on the quantitation of total Centyrin protein using liquid chromatography–tandem mass spectrometry in this interview as part of our author’s perspective series.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.