Available to view on demand. Accurate and precise biomarker measurement is critical to identifying diagnostic markers and druggable targets. Learn how quantitative mass spectrometry ensures proper biomarker measurement and characterization.
Browsing: MS (LC–MS/MS, HRMS, IMS)
Time-of-flight secondary ion mass spectrometry utilized in novel technique to map tumor cell signaling
A team from the University of Washington (WA, USA) has demonstrated the use of time-of-flight secondary ion mass spectrometry for mapping tumor cell signals in pancreatic cancer mouse models.
Biomedical research is largely centered on making new discoveries as it relates to human health and disease. The ultimate goal is to understand how human biology works and when and why it goes awry. With a strong foundation on the mechanisms of health and disease, advances in diagnostics and therapeutic interventions can be generated bringing cures to recalcitrant diseases such as cancer and neurodegenerative pathologies.
In this Editorial from Bioanalysis, the authors consider the future for hybrid assays following the US FDA recently issued guidance for hybrid assays. Find out more and access the full article, exclusively for Bioanalysis Zone members.
Find out more about the technologies involved in drug metabolism and what the future may hold for drug metabolism studies in drug discovery research in this ‘In the Zone’ feature.
As part of our ‘In the Zone’ feature on drug metabolism, we present the top 6 tips for LC–MS for drug metabolism studies. Find out more about best practice tip and tricks for LC–MS in this helpful infographic from MilliporeSigma (MO, USA).
Definitive profiling of plasma bile acids as potential biomarkers for human liver diseases using UPLC–HRMS
Find out more about this investigation into a thorough and rapid profiling of bile acids in human plasma in this article from Bioanalysis.
This week’s round-up includes the discovery of a novel method for mass spectometry and thermal desorption, as well as an update from Waters Corp (MA, USA) on their aquisition of DESI technology exclusive rights.
Find out more about ensuring the validity of biomarker measurements in this Editorial from Liam Heaney (University of Loughborough, UK).
Improving selectivity and sensitivity of protein quantitation by LC–HR–MS/MS: determination of somatropin in rat plasma
Find out more this method to improve selectivity and sensitivity of protein quantitation by LC–HR–MS/MS in this free article from Bioanalysis.