Browsing: MS (LC–MS/MS, HRMS, IMS)

BioJournals-zoom-left-1280
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The themed issue on ‘emerging technologies in mass spectrometry’ has now been published online! In this issue of Bioanalysis, authors share several emerging technologies in mass spectrometry that could, in the near future, provide dramatic changes to what is considered conventional bioanalysis.

BioJournals-zoom-left-1280
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Issue 20 of Bioanalysis volume 9 is now available, including an editorial surrounding the factors which may impact PK measurements of antibody therapeutics alongside the latest methodologies, research articles and discussions of current bioanalytical challenges. Find out more about the issue here, or on the Bioanalysis webpage.

1 EBF Trypsin poster-1
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Here we utilize a cysteine-linked antibody fluorophore conjugate to show how LC-MS methods may be optimized using a non-toxic ADC-mimic. The ADC-mimic was used to develop native and reduced SEC-MS conditions. The reduced mimic’s heavy and light chains, as well as its IdeS-proteolysis fragments, were used to develop reversed-phase LC-MS methods. A tryptic digest of the ADC mimic was used to develop a peptide mapping LC-MS method.

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