In this Bioanalysis Zone interview, Pegah Jalili (MilliporeSigma) discusses her current work in analytical R&D of biotherapeutic characterization and quantification, and what she thinks the future looks like for this field of bioanalysis.
Browsing: MS (LC–MS/MS, HRMS, IMS)
An author’s perspective: Zhengqi Ye on approaches to measure protein binding of enzymatically unstable compounds
We talk to Zhengqi Ye about the approaches she uses to measure protein binding of enzymatically unstable compounds in plasma in this interview as part of our author’s perspective series.
An author’s perspective: Wenying Jian on bioanalytical workflow for novel scaffold protein–drug conjugates
We talk to Wenying Jian about her work on the quantitation of total Centyrin protein using liquid chromatography–tandem mass spectrometry in this interview as part of our author’s perspective series.
Quantification of phenolic acid metabolites in humans by LC–MS: a structural and targeted metabolomics approach
In this research article from Bioanalysis, the authors quantified and identifed over 50 analytes from human biological matrices by HPLC, NMR and LC–MS to obtain structural information on phenolic acid metabolites.
An author’s perspective: Amanda King-Ahmad on quantitation of the peptide-1 receptor agonist liraglutide
We talk to Amanda King-Ahmad about her work on the peptide-based glucagon-like peptide-1 receptor agonist liraglutide in this interview as part of our author’s perspective series.
Complete our short survey on proteomics and be the first to receive our informative infographic collated from the survey results.
Bioanalytical workflow for novel scaffold protein–drug conjugates: quantitation of total Centyrin protein, conjugated Centyrin and free payload for Centyrin–drug conjugate in plasma and tissue samples using liquid chromatography–tandem mass spectrometry
Alternative scaffold proteins have emerged as novel platforms for development of therapeutic applications. One such application is in protein–drug conjugates, which are analogous to antibody–drug conjugates. Find out more in this research article from Bioanalysis.
Combining LC–MS/MS and hollow-fiber infection model for real-time quantitation of ampicillin to antimicrobial resistance
In this research article from Future Science OA, the authors investigate antibiotic resistance in Escherichia coli, which causes most urinary tract infections, by quantifying ampicillin in real-time using a combined LC–MS/MS and hollow-fiber infection model.
A noninvasive skin-stripping test has been developed to differentiate between eczema and psoriasis when diagnosing inflammatory skin diseases.
A new mass spectrometry system with nanomechanical resonators has been utilized to accurately measure virus capsids above 100 MDa.