In the Zone: targeted MS imaging for molecular spatial information

Mass spectrometry imaging (MSI) is a powerful analytical technique that combines mass spectrometry with spatial mapping to visualize the distribution of molecules, including pharmaceutical compounds and their metabolites, directly from tissue sections or biological surfaces.

Although MSI has proven successful, the complex nature of tissues, the presence of salts and other interferences can affect the detection of low-level analytes, making detection challenging, especially at therapeutic levels. Consequently, there is a need for enhanced capabilities, including higher sensitivity, improved efficiency and quantitative robustness. To address detection challenges, molecular visualization can be improved by leveraging the benefits of tandem quadrupole (TQ) mass spectrometers for a targeted approach utilizing Multi Reaction Monitoring (MRM) modes of acquisition.

This In the Zone feature will discuss key aspects of MSI and how the Waters Xevo™ TQ Absolute XR, coupled with the DESI™ XS targeted MSI solution, can address challenges in molecular visualization by offering unique, favorable features.

[Video by James Harvie]

INFOGRAPHIC

Infographic: Targeted MS imaging: quick, direct and detailed molecular spatial information

In this infographic, we outline some of the factors that limit the accuracy and sensitivity of mass spectrometry imaging and how the combination of two distinct technologies provides a targeted solution, addressing detection challenges and enhancing efficiency.

PODCAST

From sensitivity to selectivity: transforming mass spectrometry imaging with targeted solutions 

In this podcast, we spoke to Emmanuelle Claude, Consulting Scientist at Waters Corporation (Wilmslow, UK) and Andrew Bowman, Senior Scientist I at AbbVie (IL, USA). Together, they delve into the practical applications of MSI, discuss its transformative impact on the bioanalytical landscape, and explore how a targeted MSI solution can be seamlessly integrated into a drug discovery workflow.

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