LC–MS/MS in clinical laboratories

“It should be understood that poorly developed, inadequately validated analytical methods, lack of QC and poorly qualified technical personnel will likely result in poorly harmonized methods, erroneous measurements, and may cause harm both to patients and to the good standing of this very powerful technique.” LC–MS/MS has become one of the most powerful methodologies available in modern clinical diagnostic laboratories. Advantages of this technique over other routine methods, such as various types of immunoassays, enzymatic assays, chromatographic techniques with semi-specific methods of detection, include simplified sample preparation, faster analysis time, greater specificity and throughput. Click here for the full article.