Measurement Of Lipoproteins Using Correlation Spectroscopy

Gradient Gel Electrophoresis is the traditional method of measuring the particle size of Low Density Lipoproteins, but problems of cost, slow-speed and the variable characteristics of the gel medium, have created a need for alternative methods of measurement. One such alternative is to use Photon Correlation Spectroscopy, which could potentially address many of these concerns. This article studies the technique as applied to the particle sizing of LDLs and compares it to GGE. The particle size of Low Density Lipoproteins (LDL) is a significant clinical indicator of cardiovascular disease. LDL particles display heterogeneity in size and density, a phenomenon that...