Merck: SigmaMAb ADC Mimic

The SigmaMAb Antibody Drug Conjugate (ADC) Mimic, the newest addition to the SILu™MAb collection, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic is SigmaMAb (MSQC4), an IgG1 monoclonal antibody, conjugated to dansyl fluorophores via a LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves as the substitution for the toxic payload of a real ADC. The ADC Mimic is affordable and allows for safer and more consistent testing, making it the optimal product over real ADCs. With the help of this non-toxic product, LC-MS processes can be developed in a safer environment.

For more information, visit sigma-aldrich.com/silumab

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Application Notes for ADC Mimic

ADC Mimic Enables LC-MS Method Development

ADC-Mimic for LC-UV-MS Method Development

Non-Toxic ADC-Mimic for LC-MS Method Development