Waters: Xevo G2-S QTof

Ultimate benchtop exact mass MS performance meets next-generation software processing to achieve the most comprehensive and accurate metabolite identification studies.

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Metabolite Identification

Overview

An intelligent workflow that works as efficiently as you do.

Great instrumentation is just the starting point for successful metabolite identification. What matters most is what you do with it. Waters has designed a fast, sensitive, and efficient workflow for Met ID that combines high-resolution UPLC separations and exact-mass MS/MS and MSE with chemically-intelligent data processing utilizing MetaboLynx XS and MassFragment software. This workflow provides the most productive and unambiguous route to structural elucidation, no matter how complex your sample is.

Details

Structural elucidation is a critical step in drug metabolism studies, enabling the localization of putative biotransformations in the parent drug. In vivo and in vitro studies are used to identify major metabolites so that metabolic weak spots on the drug candidate molecule can be recognized and protected by changing the compound structure. Key for analysts in metabolite identification is maintaining high sample throughput and providing results to medicinal chemists as soon as they are available.

ACQUITY UPLC® with MS/MS or MSE addresses the complex analytical requirements of biomarker discovery by offering unmatched sensitivity, resolution, dynamic range, and mass accuracy. With workflow tools and software for comprehensive statistical processing, Waters solutions provide a turnkey approach to metabolite ID.

When used in conjunction with UPLC separations, the SYNAPT™ G2 HDMS™ and Xevo™ QTof MS systems provide an information-rich approach for metabolite detection and identification with multiple stages of fragmentation for low metabolite concentrations.

Taking advantage of this fragment ion data accuracy, MS/MS interpretation software such as the MetaboLynx™ XS Application Manager and MassFragment™ automate data processing to help you move through structural elucidation quickly and confidently.

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Metabolite Identification Application Solution with UNIFI

Overview

Know more about your metabolite ID

Waters Metabolite Identification Application Solution with UNIFI is the world’s most comprehensive metabolite identification system, assisting the biotransformation scientist, in unprecedented ways, in identifying and characterizing metabolites in both discovery and development environments. This application solution brings unparalleled ease and efficiency to routine Met ID processes. As a consequence, scientists can rapidly derive results from complex data sets, and focus their time and skill on efforts that fuel and accelerate the discovery and development process.

Pure progress

With a flexible system, now you can get the answers you need for your drug metabolism studies throughout the entire pipeline. So the right molecules can be selected early and with confidence, without unnecessary cost or wasted effort. The barriers between acquiring analytical knowledge and making information-driven decisions from discovery to market are now broken.

In discovery

Acquire knowledge and answers more quickly – allowing labs to proceed or change direction rapidly, and get the right molecules into the pipeline.

In development

Get a far deeper understanding of the drugs you’re working with – and ensure that the molecules are as well-characterized, and therefore as safe as possible.

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