Rapid and non-disruptive AAV capsid ratio determination in complex biological matrices

AAV vector production inherently generates heterogeneous populations containing both genome-filled and empty capsids, making accurate empty-to-full ratio determination critical for product quality assessment. Traditional characterization methods are often prohibitively expensive, time-consuming or technically challenging, creating barriers for efficient process development and quality control. This study introduces the Octet® AAVX Biosensor platform as a transformative solution, enabling rapid, real-time capsid quantitation across ten different AAV serotypes with exceptional precision and an impressive dynamic range.

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