Unveiling the secrets of AAVs: novel high-throughput approaches for quantification
As AAV-based gene therapies advance rapidly through clinical development, traditional analytical methods for vector characterization are becoming significant bottlenecks in research and manufacturing workflows. This comprehensive study evaluates cutting-edge alternatives to conventional techniques for measuring AAV genome titer, capsid titer and transducing capacity across multiple serotypes. By systematically comparing established methods with advanced platforms including digital PCR, bio-layer interferometry and live-cell analysis, this research demonstrates how modern analytical approaches can dramatically reduce workload, increase sample throughput and deliver faster, more robust results.
AAV-Quantification-High-Throughput-Approaches-Article-en-Sartorius
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