eBook: Robustness in bioanalysis
Speed, sensitivity and robustness are the three pillars of successful bioanalytical assays, yet achieving optimal balance between these elements remains a complex challenge in bioanalysis.
Pursuing speed through high-throughput sample cleanup methods like protein precipitation often introduces dirty matrix components into mass spectrometers. Combined with short chromatographic run times, this approach accelerates ion deposition on instrument components, compromising performance over time and requiring costly deep cleaning that can halt analysis for 1-2 days, potentially delaying critical studies and life-changing therapies.
This eBook demonstrates how intelligent analytical design and robust instrumentation can break this cycle. Through practical research articles and application notes, leading experts show how to achieve high throughput without sacrificing instrument longevity or data quality. We also feature insights from Sally Hannam, co-founder of Alderley Analytical (now part of Synexa Life Sciences) and Director at Synexa, who shares her perspective on bioanalytical workflow evolution, novel technologies, and practical strategies for managing instrument downtime in modern laboratories.
An ePub version of this content will be available soon.
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- INTERVIEW: Engineering robustness into LC–MS bioanalytical operations
- RESEARCH ARTICLE: Development of an LC–MS/MS assay for quantification of intact INSL3 in rat plasma
- INFOGRAPHIC: The maze: achieving analytical success in drug discovery
- RESEARCH ARTICLE: Development and validation of a high performance liquid chromatography–MS/MS method for determination of SOMCL-15-290 in a first-in-human study
- RESEARCH ARTICLE: Development of a sensitive LC-MS/MS assay to support human microdose study for an oral agonist of the GLP-1 receptor
- WHITE PAPER: Productivity, throughput and data quality in discovery and regulated bioanalysis
- METHODOLOGY: Development of LC–MS/MS method for cyanoenone triterpenoid determination to support CNS tissue distribution study
In association with:
CONTENTS INCLUDE:
- INTERVIEW: Engineering robustness into LC–MS bioanalytical operations
- RESEARCH ARTICLE: Development of an LC–MS/MS assay for quantification of intact INSL3 in rat plasma
- INFOGRAPHIC: The maze: achieving analytical success in drug discovery
- RESEARCH ARTICLE: Development and validation of a high performance liquid chromatography–MS/MS method for determination of SOMCL-15-290 in a first-in-human study
- RESEARCH ARTICLE: Development of a sensitive LC-MS/MS assay to support human microdose study for an oral agonist of the GLP-1 receptor
- WHITE PAPER: Productivity, throughput and data quality in discovery and regulated bioanalysis
- METHODOLOGY: Development of LC–MS/MS method for cyanoenone triterpenoid determination to support CNS tissue distribution study
In association with: