Advanced MS imaging for targeted spatial molecular analysis

What will you learn?

Here are some key takeaways participants can expect from the webinar:

1. Understanding DESI XS imaging: Learn how the DESI XS system enables high-resolution MS imaging for detailed molecular analysis.
2. Exploring the Xevo TQ Absolute: Gain insights into the advanced sensitivity and capabilities of the Xevo TQ Absolute Tandem Quadrupole mass spectrometer in MS imaging applications.
3. MS imaging in biological systems: Discover how MS imaging is used to study cellular and molecular events in situ, offering a deeper understanding of biological processes.
4. Applications in drug development and toxicology: Explore how MS imaging is advancing research in drug discovery and toxicology, providing critical insights into molecular interactions and compound distribution.
5. Visualization techniques: Understand how MS imaging allows for precise visualization of molecules, paving the way for more accurate scientific research.

Who may this interest?

1. Pharmaceutical and drug development professionals: Those working in drug discovery and toxicology will find value in understanding how MS imaging can enhance drug development, compound profiling and safety testing.
2. Researchers in biological and life sciences: Scientists studying cellular processes, molecular biology and pharmacology would benefit from learning how MS imaging aids in understanding complex biological systems.
3. Materials scientists and engineers: Professionals in the materials science field will be keen to explore how MS imaging can reveal the molecular structure and properties of materials.
4. Academic and clinical laboratories: Lab directors, researchers and technicians in both academic and clinical settings who are interested in adopting or improving MS imaging techniques for molecular analysis.
5. Scientists in analytical chemistry and instrumentation: Professionals working with mass spectrometry, analytical chemistry or instrument development will gain insights into the latest advancements in imaging technology.

Speakers

Emmanuelle Claude
Consulting Scientist,
Waters Corporation, UK

Miss Emmanuelle Claude has a master’s degree in Fine Chemistry and Business and a Master of Philosophy in Spectroscopy Analysis in Organic Chemistry and Biology. She is currently a Consulting Scientist in the Scientific Operations Department at Waters Corporation (Wilmslow, UK).

She started at Waters Corporation in October 2000 as an Application Chemist in the Proteomics and Genomics Marketing group, developing automated peptide mass fingerprint (PMF) MS methods using a MALDI-TOF mass spectrometer.

Over the years, she has developed several methods in the proteomics analytical space using MALDI-TOF and naturally moved into starting the development of mass spectrometry imaging (MSI) at Waters Corporation nearly 20 years ago.

She has been involved with hardware and software R&D to ensure that the solutions are fit-for-purpose for the MSI community and beyond. She has worked extensively with the main MSI leaders in Europe and the US such as Professor Heeren in the Netherlands, Professor Clench and Dr Bunch in the UK, and Professor Caprioli in the US. She has been a Principal Scientist since 2014, became a Consulting Scientist in 2021 and is now part of the MS imaging porfolio at Waters where data are generated for collaborations and marketing activities (i.e. application literature, customer presentation, papers, posters, etc.), as well as hardware and software requirements that are defined for the R&D teams. The team evaluates and develops new applications and methods for imaging by both MALDI and DESI mass spectrometry, supports sales with customer visits and demonstrations in laboratories worldwide.

Andrew Bowman
Senior Scientist I,
AbbVie Inc (Chicago, IL)

Andrew Bowman is a drug metabolism and disposition scientist in the Quantitative, Translational, and ADME Sciences department of AbbVie, Inc. His focus has been on the development of new and targeted mass spectrometry imaging platforms and their use in the analysis of drugs in tissue. Andrew is a graduate of the doctoral program from Maastricht University’s (Netherlands) ‘Maastricht MultiModal Molecular Imaging Institute (M4I)’, where he focused on the detection and analysis of lipids in mass spectrometry imaging.

Nari Talaty
Principal Scientist II,
AbbVie Inc (Chicago, IL)

Nari Talaty is a Principal Scientist in the drug metabolism and disposition (DMD) team in the Quantitative, Translational, and ADME Sciences department of AbbVie, Inc. Nari leads a team within DMD whose research is focused on ADME studies and technology developments in mass spectrometry. He has implemented the DESI technology for diverse applications across the pharma pipeline. Current applications include developing novel targeted mass spectrometry imaging applications. He has a PhD in Analytical Chemistry from Purdue University (IN, USA) with a focus in mass spectrometry under the guidance of Professor R G Cooks.