Solid phase microextraction: sketching the future of microsampling in bioanalysis
This webinar will focus on the application of SPME for onsite analysis of drug concentrations within a pharmaceutical setting. Taking microsampling a step further, the potential benefits of combining sampling, sample preparation and extraction in one step without the need for blood withdrawal will be uncovered. An insight to experimental findings and how to overcome possible challenges when evaluating this technique will be highlighted. A novel ionization approach for direct SPME-MS will be outlined and a detailed outlook for the future of SPME as a revolutionary microsampling technique for bioanalysis will be discussed.
What will you learn?
- What SPME is
- The potential advantages of SPME as a microsampling tool for preclinical studies
- How SPME measures unbound concentrations and determines protein binding values
- Considerations for developing and validating a bioanalytical SPME method
- An overview of a novel ionization technique, combining SPME with MS without chromatographic separation
Who may this interest?
- Bioanalytical and DMPK scientists
- Toxicologists, biologists and pharmaceutical scientists
- Laboratory animal professionals and clinicians
- Academics and research students
Sheelan Ahmad is a Senior Scientist within the Drug Metabolism and Pharmacokinetics Department of GlaxoSmithKline Pharmaceuticals R&D. She has worked for GSK for over 8 years supporting numerous GLP and non-GLP, preclinical and clinical studies. Prior to this, Sheelan obtained her Pharmaceutical Science BSc with first class honors from the University of Hertfordshire, in 2006. She is currently enrolled as a part-time PhD student while undertaking a dynamic expert role at GSK. Her current interests include new microsampling techniques with a special focus on the application of solid phase microextraction to pharmaceutical bioanalysis.
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