Overcoming challenges for preclinical bioanalysis of ADC therapeutics
Tuesday 21 April 2026
07:00 [PDT] 9:00 [CDT] 15:00 [BST]
From assay strategy to data confidence: tackling preclinical bioanalytical challenges in ADC development
Antibody-drug conjugates (ADCs) are a class of precision-based cancer therapies that have gained significant attention in the last decade of drug development. However, their complex molecular design has created unique challenges for developing bioanalytical methods, which typically involve both LC–MS- and ligand-binding-based assays. Further complications arise in preclinical stages due to the typical expedited timelines for ADC pipelines and the limited availability of reagents used to establish analytical assays.
In this webinar, we share a common bioanalytical strategy for ADCs and a case study demonstrating the approach we use to overcome challenges encountered in preclinical bioanalysis of ADCs.
What you will learn?
- Understand the key bioanalytical challenges unique to ADC therapeutics.
- Learn how to apply LC–MS and ligand-binding assays strategically to generate reliable, decision-ready data for complex ADC molecules.
- Discover practical solutions for advancing ADC programs despite limited reagent availability in early development.
- Gain a framework for building fit-for-purpose bioanalytical strategies that keep pace with accelerated preclinical ADC timelines.
- See a real preclinical ADC case study in action, highlighting common pitfalls, mitigation strategies and lessons learned.
Who may this interest?
- Bioanalytical scientists
- Business executives in the pharmaceutical industry
- Scientists who have ADC therapeutic products/projects in their pipelines
Nan Jia
Subject Matter Expert in Bioanalysis
Dr Jia currently serves as the Assistant Director of the the Bioanalysis Division in the Toxicology Department of WuXi AppTec, focusing on leveraging bioanalytical technologies to aid drug research and development. Nan received a PhD degree in Biochemistry from Imperial College London (UK). Before joining WuXi AppTec, he worked as a post-doctoral researcher at Beth Israel Deaconess Medical Center/Harvard Medical School (MA, USA), with his primary research focus on the bioanalysis of carbohydrates. Dr Jia has authored 11 peer-reviewed publications.
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