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The role of metabolomics in characterizing the human exposome

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 “…[the exposome concept]represents a paradigm shift in molecular epidemiology/environmental toxicology, with the focus on complex human exposure profiles (‘top-down’), rather than on individual chemical exposures (‘bottom-up’).”

In this commentary, the potential of metabolomics/metabonomics/metabolic profiling (summarized in [1]) as a key platform for contributing to exposome studies is discussed. An overview of the exposome concept and recent developments is provided, alongside a brief summary of the technological platforms that currently underpin metabolic profiling. The article concludes with a personal perspective on the short- and medium-term challenges faced by those in the metabolic profiling community addressing the area of exposome science.

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