Bioanalysis Zone

Microspray and microflow LC–MS/MS: the perfect fit for bioanalysis


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The advantages of microflow LC (MFLC) and nanoflow liquid chromatography coupled with a mass spectrometer are well known and include improved signal, low solvent consumption, reduced matrix effects and reduced source contamination [1]. In the past, microflow and nanoflow MS/MS have mainly been used in academic and fundamental research labs requiring high sensitivity analysis with limited sample volumes for qualitative or comparative analysis.

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  1. Very good article and assessment of microflow LC/MS. Another article published on this same subject in Bioanalysis Vol. 7, No. 7, Pages 857-867 titled “Practical applications of integrated microfluidics for peptide quantification” highlights the same benefits of increased sensitivity, decreased solvent consumption and a number of applications of microflow LC/MS for bioanalytical applications.

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