Analytical applications of nanoparticles in MALDI-MS for bioanalysis

Recently, the rapid development of nanotechnology has enabled the analytical community to integrate processes with MALDI-MS for the analysis of various biomolecules. This article presents the recent progress on nanomaterials as extracting probes in single-drop microextraction, in liquid–liquid microextraction and as affinity probes for the enrichment of trace level biomolecules prior to their identification by MALDI-MS. The unique electronic, optical and physicochemical properties of nanostructured materials provide excellent prospects for enrichment of ultra-trace biomolecule events with electronic signal transduction, and yielding a new generation of bioanalytical approaches/devices with exciting advances [1]. Recent years, the extraordinary properties of nanomaterials have sparked...