Bioanalysis Zone

Poster presentations from the 10th Workshop on Recent Issues in Bioanalysis (WRIB)

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The Bioanalysis Zone and Bioanalysis team attended this year’s 10th Workshop on Recent Issues in Bioanalysis (WRIB; FL, USA), on the 18–22 April 2016. As usual the event had a host of excellent talks by leadingexperts in all aspects of bioanalysis, with sessions on small molecules, large molecules, biomarkers, LBA, LC–MS and immunogenicity, plus a full program of training workshops and discussions for the forthcoming White Paper.

We were particularly proud to support the WRIB Poster Award, presented by our journal Editor Sankeetha Nadarajah to Yang  Xu, Shaifali Gupta and Jian Chen. Click on the winners’ names to see their winning posters along with an exclusive interview. Some of the other presenters have also agreed to share their posters with us – you can see these below.

Also included below is a poster presented at the AAPS National Biotechnology Conference held on the 16–18 May 2016.


10th WRIB

Poster: SPARCL™: Use of a novel technology in validation of a Non-Human Primate C-Reactive
Protein assay in serum

Iohann Boulay , Maude Bigras , Karine Blouin , Karine Dumaresq-Doiron , Renée Riffon, Chris Chadwick

Summary: A novel method for the quantification of CRP in monkey serum samples, SPARCLTM, was successfully validated. The SPARCL assay presents an advantage of short assay run times since no washing is required. It allows high sample throughput, and the analytical range covers relevant concentrations in non-human primates.

Poster: Flow Cytometric Analysis of B, NK and T cell Subpopulations in Whole Blood Samples from Non-Human Primate

Iohann Boulay, Selly Hau Yee Hung, Vanessa Plouffe, Karine Blouin, Daniela Andreeva, Julie Mercier, Frédéric Bouchard, Karine Dumaresq-Doiron

Summary: Overall, the flow cytometry methodology described herein was found to be suitable for the exploration of the population kinetics of various T cell subsets, as well as NK and B cells. The current panels allow characterization of the major contributors in the depletion/recovery phase of the lymphocyte population in more depth. The methodology is a single-platform without the need of counting beads. Furthermore, it possesses potential precision improvements over other single-platform methods requiring the spiking of counting beads and two-platform methods requiring a second analysis of the sample to obtain absolute count measurements.

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AAPS-NBC

Rapid & comprehensive comparison of five versions of bevacizumab: Avastin versus its biosimilars
Chris Becker, Yong Kil, Pierre Allemand, St John Skilton, Eric Carlson, David Morgenstern, Beatrix Ueberheide  (Protein Metrics)

Summary: As the speed and sensitivity of mass spectrometers continue to improve, there is a concomitant need for software tools to provide rapid yet detailed and robust analysis of complex MS datasets. Here the authors present a study showing comprehensive analysis of five different productions of a therapeutic antibody – bevacizumab (Avastin) — using the Protein Metrics suite of analysis software.

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