Bioanalysis Zone

Poster: Total Antibody Quantification of the Antibody Drug Conjugate, Ado-Trastuzumab Emtansine in Rat Plasma Using the BioBA Solution


About the Winning BioBA Solution Workflow Poster
Due to their heterogeneous nature, antibody-drug-conjugates (ADCs) require multiple bioanalytical assays to quantify their various forms. One such assay, the total antibody measurement, includes different protein sample preparation techniques that when combined with LC-MS/MS analysis amount to total antibody measurement, and this award winning Poster! The purpose of the study was to develop an immunoaffinity LC-MS/MS method for the selective quantitation of the ADC, Ado-trastuzumab emtansine using the BioBA sample prep kit.
(Conjugated Antibody Species + Unconjugated Antibody = Total Antibody Measurement)

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