The ability to efficiently and robustly characterise drugs and metabolites during DMPK studies is a vital part of the drug development process. Current LC-MS systems, incorporating either high sensitivity triple quadrupole or high resolution instruments, already allow for rapid analysis with a high degree of selectivity, but uncertainty in the identification of drug-related components can still be encountered. Issues are more commonly observed during the analysis of complex matrices (e.g. bile, urine, faeces and plasma), samples containing a large number of closely eluting drug-related components or when analytes are present at a low abundance. Instruments that incorporate ion mobility provide an extra resolution step to the LC- MS process, in addition they allow CCS (collisional cross section) values to be generated. The Vion IMS Q-Tof instrument (Waters) enables drug metabolism
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