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New high-resolution mass spectrometers and software showcased by Thermo Fisher Scientific


Thermo Fisher Scientific (MA, USA) has expanded its Orbitrap platform with the release of the Orbitrap Exploris 240 and Orbitrap Exploris 120, two new-generation high-resolution mass spectrometers. A range of new software also showcased at ASMS 2020 Reboot promises to improve confidence, versatility and productivity.

The Orbitrap Exploris 240 has been designed to give the performance required for high-throughput analyses, biopharmaceutical characterization, proteomics and metabolomics research. Thermo Fisher explain that the new system will increase accuracy facilitating confident scale up and reducing time to result.

Orbitrap-exploris-240-high-resolution mass spectrometers

Thermo Scientific Orbitrap Exploris 240 mass spectrometer. Image courtesy of Thermo Fisher Scientific

The Orbitrap Exploris 240, is one of the latest in the Orbitrap Exploris platform and is designed to deliver sensitivity, mass accuracy and resolving power across a wide dynamic range. With new generation system architecture and instrument control software, the system aims to provide simple and powerful data acquisition capabilities for small- and large-molecule applications.

The Orbitrap Exploris 240’s functionalities include a positive and negative mode switching to ensure sample coverage as well as supporting Thermo Fisher Scientific’s AcquireX, a data acquisition workflow that can be used to facilitate automation.

Iain Mylchreest (Vice President, Research and Development, Analytical Instruments, Thermo Fisher Scientific) explained: “Scientists are seeking technologies that can streamline and speed proteomics studies to clinical applications, reduce time to market for candidate biotherapeutics and address the growing challenge of characterizing novel chemical entities in small-molecule studies. As part of our expanded portfolio of new-generation instruments, the Orbitrap Exploris 240 mass spectrometer delivers the high performance and versatility needed to drive productivity across multiple applications.”

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In addition to the Orbitrap Exploris 240, Thermo Fisher have released the Orbitrap Exploris 120, which promises operational simplicity and ruggedness across small molecule applications. The Orbitrap Exploris 120 is designed to deliver in-depth analysis of multiple complex samples for scientists working across small molecule applications, with operational simplicity. User-friendly interfaces are set to reduce training time and provide a fast ramp-up time for new users to achieve robust data.

Orbitrap Exploris 120 Mass Spectrometer

Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer. Image courtesy of Thermo Fisher Scientific

Regarding the Exploris 120, August Specht (Vice President, Research and Development, Chromatography and Mass Spectrometry, Thermo Fisher Scientific), commented: “Scientists running small molecule studies and applications in areas such as metabolomics, environmental analysis, metabolite identification, forensic toxicology and anti-doping, require complete sample coverage in their analyses, without compromising productivity. The Orbitrap Exploris 120 mass spectrometer was designed specifically for laboratories to safeguard their current assays and enhance their provision of high-throughput and differentiated services, while simultaneously minimizing required training and method development times.

The two new high-resolution mass spectrometers, the Orbitrap Exploris 240 and the Orbitrap Exploris 120, are the latest to join the Thermo Fisher Scientific Orbitrap Exploris portfolio which launched in 2019 with the Exploris 480. Both the Exploris 240 and Exploris 480 high-resolution mass spectrometers are compatible with the Thermo Scientific FAIMS Pro interface which facilitates the identification of proteins and peptides.

Alongside the new high-resolution mass spectrometers, Thermo Fisher Scientific have released a suite of new software functionalities to facilitate data acquisition and processing.

Updated Proteome Discoverer software utilizes deep learning tools to improve mass spectra prediction and peptide identification. New BioPharma Finder software aims to improve intact protein analysis, sub-unit mass analysis, peptide mapping and oligonucleotide analysis.

The latest iteration of Compound Discoverer software is designed to support small molecule researchers through enhanced characterization capabilities. The latest Xcalibur software brings Thermo Fisher’s AcquireX data acquisition workflow to the Orbitrap Exploris range of high-resolution mass spectrometers, enhancing opportunities for automation.

Thermo Fisher Scientific also highlight the potential benefits of the mzCloud. A large cloud-based mass spectral fragmentation library that could be used in small molecule application to facilitate compound identification.

The new high-resolution mass spectrometers and range of enhanced software functionalities are being showcased at the virtual online event, ASMS 2020 Reboot. Thermo Fisher Scientific hope that their new mass spectrometry systems and software will enable scientists to broaden their mass spectrometry-based research by improving workflows in proteomics, biotherapeutics and clinical applications.

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