A smartphone digital image colorimetric method based on nanoparticles for determination of lamotrigine
Sefid-Sefidehkhan Y, Mokhtari M, Jouyban A, Khoshkam M, Khoubnasabjafari M, Jouyban-Gharamaleki V & Rahimpour E | Bioanalysis, 15(15), 915-926, (2023)
Keywords: • image analysis • lamotrigine • parallel factor analysis • PhotoMetrix • smartphone
Aim: A colorimetric approach for quantification of lamotrigine using spectrophotometric and smartphone image analysis is described in this study. Methods: For full optimization and validation procedures, UV-visible spectroscopy was used, and image analysis was carried out with the help of an app (PhotoMetrix PRO®). Then, as a multivariate calibration method, parallel factor analysis was used for data analysis. Results: The results demonstrated the capacity of these methods to estimate lamotrigine concentrations in the range of 0.1–7.0 μg.ml-1 in exhaled breath condensate, indicating the value of using digital images and smartphone applications in combination with chemometric tools. Conclusion: The image analysis can be superior for its fast and reliable lamotrigine analysis in biological samples.
