KCAS Bio
KCAS Bio is a global contract research organization (CRO) specializing in bioanalytical and biomarker services to support drug development from early discovery through regulatory approval. With more than 45 years of experience serving pharmaceutical and biotechnology sponsors, KCAS Bio has contributed to over 315 drug approvals on the market today. The company has developed more than 6,200 proprietary and non-proprietary assays and has successfully completed >25 FDA regulatory audits with no major findings.
KCAS Bio operates laboratory facilities across the United States and Europe, along with a strategic alliance in Australia, enabling global support for regulated bioanalysis. Core capabilities include small and large molecule bioanalysis, biomarker services, immunogenicity testing, cellular and molecular assays, flow cytometry, as well as clinical trial kitting and sample management. The company is heavily involved in advanced modalities.
KCAS Bio is GLP-compliant, and recognized for its scientific expertise, regulatory compliance, and operational reliability, helping sponsors reduce risk and accelerate timelines in the development of safe and effective therapies.
From LBA to LC-MS/MS: Solving the PK/PD Disconnect in Biotherapeutic Stability
Understanding Hybrid LC-MS/MS Bioanalysis
When to Choose Quantitative PCR vs Digital PCR
Comparing Immunogenicity Assessment Methods
A Day in the Life of a Sample: How KCAS Bio Ensures Sample Integrity at Every Step
Panel discussion: bioanalytical considerations for oligonucleotide assessment strategies
Biomarker assay development: qualification vs validation debate
Panel discussion: evolving best practices in high-complexity flow cytometry
Bioanalytical considerations for immunogenicity of cell and gene therapies
Panel discussion: LBA and LC–MS/MS hybrid assays
Evolving best practices: considerations for conventional and spectral flow
Panel discussion: novel techniques and the new age of biomarkers
KCAS Bio specializes in the following services:
Bioanalysis
- Pharmacokinetics/ Toxicokinetics:
- LC-MS/MS, Hybrid LC-MS/MS, LBA, qPCR, ddPCR
- LNPs:
- LC-MS/MS, Hybrid LC-MS/MS
- Receptor occupancy:
- Flow cytometry
- Immunogenicity/ADA:
- LBA
- Biodistribution:
- qPCR, ddPCR
- Neutralizing antibodies assays:
- Cell-based, plate based
- Dose formulation analysis
- SEC, UPLC
Pharmacodynamics
- Primary endpoints
- Functional assays
- Secondary endpoints/ exploratory assays
Biomarkers
- Soluble biomarkers:
- LBA, qPCR, ddPCR, LC-MS/MS, MSD
- Cellular biomarkers:
- ELISpot, flow cytometry, qPCR, ddPCR, single-cell proteomics
Support
- Formulation analysis
- Sample kits (clinical/non clinical)
- Bio-repository
Learn more at www.kcasbio.com or follow us on twitter @KCASBio
Website:
www.kcasbio.com
Email:
[email protected]
Telephone:
913-248-3000
Address:
10830 S Clay Blair Blvd
Olathe, Kansas
66061
USA