Powering volumetric, non-invasive self-collection of first-void urine

First-void urine — the initial portion of urine expelled — contains higher levels of biomarkers such as DNA, RNA and proteins originating from host cells, cell-free DNA and extracellular vesicles. This type of sample is valuable for research, particularly in its potential for detecting certain diseases and infections due to its enriched content. The Colli-Pee™ UCM™ device is designed to simplify and standardize the collection of first-void urine. It works by diverting the first 4–40 mL of urine into a dedicated sample tube, ensuring a precise quantity is collected while any excess is discarded. During collection, the urine is combined with a prefilled UCM™ preservative, which maintains the stability of DNA from bacteria and viruses for up to 7 days at room temperature.

For HPV detection, first-void urine collected using the Colli-Pee™ UCM™ device potentially offers a non-invasive alternative to traditional vaginal swabs or samples collected by clinicians. Studies have shown that it provides non-inferior sensitivity and specificity for identifying HPV, making it well-suited for research applications in this field.

Download this resource from DNA Genotek™ to learn more about the Colli-Pee™ device and its use in HPV research. For further information on the Colli-Pee™ device, listen to our interview with Tara Crawford Parks, PhD.

In partnership with: