In this eBook, we explore the range of bioanalytical approaches and strategies for oligonucleotide analysis. Oligonucleotides offer a promising new modality of disease targeting that were once thought to be ‘undruggable’ via small molecule drugs or monoclonal antibodies. While interest in oligonucleotide therapeutics has increased, their analysis, validation and regulation must also be considered. The appropriate bioanalytical strategies must be implemented to properly assess a potential oligonucleotide therapeutic.
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