eBook: immunogenicity and the promise of cell and gene therapies


As part of this eBook, we explore the best practices in bioanalytical support of immunogenicity evaluations in cell and gene therapy development, giving an insight into method design, development and validation. We also review the use of AAV vectors for the delivery of cell and gene therapies, as they can drive transgene expression whilst not integrating into the host genome. Different AAV isotypes are capable of infecting different cell types in humans, allowing for specific targeting of distinct tissues by choosing the right AAV vector.

 

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[Cover design by Hannah Morton]