Enhancing clinical research with pharmacogenomics: a practical perspective

Zhang XT, Blacutt J, Lloyd T et al. | Bioanalysis, 17(06), 399–411, (2025) Keywords: • pharmacogenomics • PGx platform • phenotype • drug metabolism • drug transport • drug target • genetic biomarker • personalized medicine Pharmacogenomics (PGx) is transforming therapeutic development by providing insights into how genetic variations influence drug response, safety, and efficacy. This review provides a structured analysis of PGx in clinical research, beginning with an overview of key genes involved in drug metabolism, transport, and targets. Following this, it examines strategies for identifying PGx-relevant genes, including phenotype-driven, hypothesis-driven, population-focused, and clinical-driven approaches. Technical platforms such as...