Using innovative tools for in vitro absorption, distribution, metabolism and excretion studies to efficiently and effectively support drug development
Wang K, Sun D, Zhu B, et al. | Bioanalysis, 15(3), 149-159, (2023)
Keywords: • ADME study • CRO • drug metabolism • information system • innovative tools • LC–MS
Drug development is a complicated and lengthy process requiring a significant amount of intellectual and capital input, as well as extensive collaborations among various organizations and institutions. Contract research organizations play important roles at some or even all stages of the drug development process. To provide better service in in vitro drug absorption, disposition, metabolism and excretion studies, maintain data accuracy and promote work efficiency, we developed an integrated information system termed the ‘Drug Metabolism Information System’, and it is being used routinely by our drug metabolism department. The Drug Metabolism Information System assists scientists with assay design, data analysis and report drafting and thus reduces human error.
