In the Zone: creating rugged small molecule methods
The implementation of small molecule methods for bioanalytical projects will affect the quality, throughput and reputation of a laboratory. The method must be durable, accurate and precise, and when done correctly, will be optimized to fit the ethos of the laboratory. Good assay development should be done in the least amount of time and resources possible for productivity, but this should be balanced with a fit-for-purpose attitude. Explore our resources in collaboration with Alturas Analytics to learn more about how to create rugged small molecule methods.
[Video by Kristian Baycroft-Willmott]
INFOGRAPHIC
Infographic: Method development for small molecules: a step-by-step guide
Developed in collaboration with Alturas Analytics, Inc. (ID, USA), we explore the mass spectrometry platform options available to users and how each is beneficial depending on the assay’s sensitivity requirements. Get a concise summary of liquid chromatography method development steps, with practical guidelines and tips from Alturas’ experts. This infographic also outlines key extraction method development criteria and offers strategies for addressing both enzymatic and chemical instability challenges, ensuring analyte stability throughout your analytical workflow.
INTERVIEW
Small molecule method development strategies with Chad Christianson
In bioanalytical method development, efficiency and quality must coexist despite their competing demands. In this interview, Chad Christianson shares his insights on maximizing laboratory resources without compromising scientific integrity and describes how he and his team determine methods to be “good enough” for study initiation. Chad navigates the advantages and limitations of different mass spectrometry platforms and reveals his pragmatic approach to method development.
WEBINAR
Optimizing method development for efficiency, throughput and data quality
If done poorly, small molecule LC–MS/MS methods will impact the quality, throughput and reputation of a laboratory. When done correctly, the method is durable, accurate, precise and optimized to fit the ethos of the laboratory. Minimizing the time and resources it takes to develop a good assay is vital for productivity but must be balanced with a fit-for-purpose attitude. In this webinar, you will learn the basic principles of developing a high-quality small molecule LC–MS/MS method.
RESOURCES
In the Zone: The bioanalyst – challenges and solutions
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