eBook: Precision bioanalysis for every molecule
As we navigate the complexities of modern healthcare and biotechnology, the ability to analyze molecules with precision and accuracy has become more critical than ever. Liquid chromatography with tandem mass spectrometry (LC–MS/MS) is a powerful technique that has revolutionized bioanalysis by providing unparalleled sensitivity and accuracy, enabling the detection of trace amounts of analytes that might otherwise go undetected. LC–MS/MS systems address specificity, sensitivity and reproducibility challenges, delivering consistent, reproducible results. By minimizing data variability, these systems enhance interpretation and validation processes, streamline workflows, and reduce time and operational pressures.
Here, we explore the criticality of precision bioanalysis for every molecule and highlight a medley of approaches, including LC–MRMHR and LC–MRM.
CONTENTS INCLUDE:
- INTERVIEW: A 2-fold revolution: MS approaches for the bioanalysis of oligonucleotide therapeutics
- EXPERT OPINION: Sensitive LC–MRMHR approach for cyclic peptide quantitation in human plasma
- TECHNICAL NOTE: Low-ng/mL quantitation of glucagon-like peptide-1 (GLP-1) analog in rat plasma
- RESEARCH ARTICLE: Quantitation of TAK-981 in human plasma via LC–MS/MS and its application in clinical trials
- TECHNICAL NOTE: Ultra-sensitive LC–MRM analysis for trastuzumab-emtansine quantification in rat plasma
- REVIEW ARTICLE: LC–MS/MS: a powerful tool for modern analytical science: Fundamentals, techniques, applications and innovations
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