Small extracellular vesicle biomarkers in breast cancer: a real-time snapshot for early diagnosis and prognosis?
Gajula S & Nalla L | Bioanalysis, 15(7), 367-370, (2023)
Keywords: • biomarkers • breast cancer • exomeres • LC–MS/MS • liquid biopsy • next-generation sequencing • protein quantification • proteomics • small extracellular vesicles • supermeres
Breast cancer accounts for about 30% of female cancer cases and is a worldwide public health concern [1–3]. Breast cancer was newly diagnosed in roughly 284,200 females in the USA in 2021, causing 43,600 deaths [4]. Early detection of breast cancer is crucial for successful treatment options and a decreased risk of cancer metastasis. Breast cancer is a dynamic and heterogeneous condition characterized by distinct somatic mutations associated with modifications in the expression of genes and proteins. Discrete biomarker profiles impact tumor recurrence, treatment resistance and mortality and necessitate various therapy modalities.
