Stable isotope labeled metabolomics improves identification of novel metabolites and pathways

“The recent surge in bioanalytical and bioinformatics methods developed for metabolomics studies have significantly improved our ability to expand isotope-labeling studies … bringing us closer to the promise of a true systems biology understanding of the metabolism for many organisms.”

Metabolomics is a rapidly growing field of postgenomic biology that enables system-wide studies of cellular metabolism. Stable isotope labeling is an established approach for investigation of the dynamics of metabolic pathways. The combination of these two approaches promises to provide a comprehensive understanding of metabolic networks in biological systems. Metabolomics involves the semi-quantitative detection of many small molecules (<1500Da) in a biological system using modern bioanalytical platforms such as NMR, GC–MS, CE–MS and LC–MS.

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