Critical reagents: an interview with Ashley Brant

Interviews LBA

In this interview Ashley Brant, Senior Scientific Director at Eurofins Bioanalytical Services (MO, USA), discusses the role of critical reagents and why they are integral in relation to assay performance. She highlights the different challenges associated with changing reagents and how Eurofins evaluate the expiry/re-test date of a critical reagent. The interview concludes with her opinion on how the management of critical reagents will evolve over the next 5 years.

About Ashley Brant:

Ashley works closely to drive new technology and overall strategy for growth providing biologics-focused bioanalytical solutions for clients. She serves as a single point of contact for client development programs with a focus on expanding large molecule capabilities as well as provides strategic scientific oversight of study designs. She is the scientific and technical advisor for clients and internal teams for development, validation, and application of assays to ensure compliance with regulatory requirements. During Ashley’s distinguished scientific career, she has held positions of increasing responsibility within the biopharmaceutical industry. After receiving her MS from the University of Michigan, Ashley became a bioanalytical consultant assisting clients with project set-up and clinical study management and design. Subsequently a Principle Investigator and Associate Scientific Director with small to mid-size bioanalytical CRO’s where she managed the ligand binding method development and validation workflows. An accomplished leader in the field of bioanalysis and large molecule drug development, he has been involved in various industry organizations, including AAPS and WRIB and is an invited speaker at multiple industry events.

Questions discussed:

  1. Can you explain why critical reagents are important in relation to assay performance?
  2. What are the challenges associated with changing reagents?
  3. At Eurofins you utilize a Test Method Summary Sheet, could you explain how this recording system works?
  4. How do you evaluate the expiry date or a re-test date of a critical reagent?
  5. Lastly, how do you see the management of critical reagents evolving over the next 5 years?

More resources:

Webinar: Critical Reagent Management Strategies to Ensure Method Performance while Reducing Timelines and Cost

 

 

 

Technology digest: why is it important to develop a critical reagent management strategy?

 

 

 

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