Distinct Advantages of an Internal Ion Mobility Cell for Drug Discovery and Development

This presentation is the 2nd in the series of 3 webinars brought to you by Waters Corporation and Bioanalysis Zone on “Scientists Helping Scientists Meet New Challenges in Pharmaceutical Drug Discovery and Development”.

In this webinar Dr. Filip Cuyckens of Janssen R&D and Russell Mortishire-Smith of Waters Corporation will discuss “Webinar: Distinct Advantages of an Internal Ion Mobility Cell for Drug Discovery and Development”.

Topics Covered:

  • Learn how the optimum geometry and modes of acquisition can impact robustness, sensitivity, and help deliver quantitative and highly specific information to the DMPK scientist
  • Understand how ion mobility works, by embedding an internal separation device inside the mass spectrometer to increase the full range resolving power of HRMS and to enhance selectivity in MS and MSE datasets
  • Understand how MS3 or MS4 spectra generated on a QTof system can be used for the identification of positional isomers of metabolites

Panelist Biographies:

Dr. Filip Cuyckens

Principal Scientist
Drug Safety
Janssen R&D
Filip Cuyckens is a Principal Scientist at Janssen R&D. He has earned a Pharmacist degree in 1998 at the University of Antwerp, Belgium, where he also obtained a degree of Industrial Pharmacist in 2002 and a Ph.D. in 2003. He is currently responsible for the Analytical Sciences group, comprising the Biotransformations lab and non-regulated Bioanalytical Sciences, within the Drug Metabolism & Pharmacokinetics department at the Janssen R&D site in Belgium.  Filip is an active member of the analytical chemistry community. He has (co) authored 39 publications and presented broadly in the area of liquid chromatography and mass spectrometry.

Dr. Russell Mortishire-Smith
Senior Consultant Scientist
Pharmaceutical Business Ops
Waters Corporation
After a bachelor’s degree in chemistry at the University of Leeds, Russell obtained his doctorate from Cambridge University in natural product isolation and characterization, and followed this with a post-doctoral fellowship at The Scripps Institute, La Jolla using NMR spectroscopy to determine the solution structures of a variety of transcription-regulating proteins. In 1993, he joined Merck & Co’s Neuroscience Research Centre in Harlow, UK, as an analytical scientist, and over the following 13 years had the privilege of working on a wide variety of drug discovery issues, spanning from chemistry support, open access technology for both NMR and LC/MS, metabonomics, and ultimately, drug metabolite characterization, where he took a particular interest in automated approaches to the analysis of high resolution datasets. In 2006, he moved to work for Janssen Pharmaceutica (Beerse, Belgium), as the functional lead for the European Discovery DMPK organization, where his continued interest in the application of high resolution LC/MS led to publications on the use of ion mobility for distinguishing regioisomeric metabolites, and one of the first practical automated approaches for hotspot localization. Following a variety of successful collaborations with Waters Corp. over nearly 20 years, Russell joined Waters in early 2013, supporting Waters’ commitment to developing solutions to fit customer needs.