Bioanalysis Zone

In vivo solid-phase microextraction sampling: a promising future

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“The opportunities presented by in vivo solid-phase microextraction are clearly exciting and numerous, so the main question becomes: is the bioanalytical community finally ready to embrace microextraction methods such as this one and explore their full potential?”

The majority of bioanalytical procedures for blood and tissue analysis rely on the initial withdrawal of the biological sample. The resulting sample is subsequently extracted to reduce its complexity and analyzed using an appropriate technique such as LC–MS. The goal of this editorial is to discuss an alternative workflow whereby sampling and sample preparation steps are carried out directly in the vein or tissue of the living system under study and to highlight situations when this in vivo sampling approach has significant advantages over ex vivo approaches.

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