Publication / Source: Bioanalysis 5(15)
Authors: Creek DJ
“The recent surge in bioanalytical and bioinformatics methods developed for metabolomics studies have significantly improved our ability to expand isotope-labeling studies … bringing us closer to the promise of a true systems biology understanding of the metabolism for many organisms.”
Metabolomics is a rapidly growing field of postgenomic biology that enables system-wide studies of cellular metabolism. Stable isotope labeling is an established approach for investigation of the dynamics of metabolic pathways. The combination of these two approaches promises to provide a comprehensive understanding of metabolic networks in biological systems. Metabolomics involves the semi-quantitative detection of many small molecules (<1500Da) in a biological system using modern bioanalytical platforms such as NMR, GC–MS, CE–MS and LC–MS.
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