Tech Note: Low-ng/mL quantitation of GLP-1 analog in rat plasma
This Technical Note presents a sensitive LC–MS/MS approach for low‑ng/mL quantitation of the GLP‑1 analog semaglutide in rat plasma, addressing key bioanalytical challenges associated with low bioavailability and limited sample volumes. The method demonstrates how optimized triple quadrupole mass spectrometry enables selective, reproducible measurement of high‑potency peptide therapeutics in complex matrices. Together, it highlights core principles of modern quantitative bioanalysis essential for pharmacokinetic and drug development studies.
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