Video: Antibody drug–conjugates characterization (Waters Corporation)

Chromatography MS (LC–MS/MS, HRMS, IMS)

This video discusses powerful analytical tools which can be used to interrogate and understand ADCs. In particular, it outlines:

  • Characterizing ADCs with hydrophobic interaction chromatography
  • Deriving DAR via native UPLC/MS
  • Resolving positional isomers by 2D UPLC/MS
  • Identifying conjugation by peptide mapping