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Video: Antibody drug–conjugates characterization (Waters Corporation)

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Mass Spectrometry

This video discusses powerful analytical tools which can be used to interrogate and understand ADCs. In particular, it outlines:

  • Characterizing ADCs with hydrophobic interaction chromatography
  • Deriving DAR via native UPLC/MS
  • Resolving positional isomers by 2D UPLC/MS
  • Identifying conjugation by peptide mapping
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