Publication / Source: Bioanalysis 7(13)
Authors: Rao C, Rangan VS, Deshpande S
“…the mode of attachment of the payload linker to the antibody must have a perfect fit for its success.”
With the approval of Adcetris to treat Hodgkin’s lymphoma and Kadcyla to treat Her2 positive advanced breast cancer, antibody–drug conjugates (ADCs) are fast becoming a well-proven strategy to treat cancer. For successful development of ADCs, several parameters at early stages in research need careful examination.