Original Publication Date: 1 October, 2017
Publication / Source: Bioanalysis 9(22)
Authors: Ramanathan R, King-Ahmad AJ, Holliman CL & Rodrigues AD
Aim: Coproporphyrin-I (CP-I) and coproporphyrin-III (CP-III) in plasma and urine have been proposed as biomarkers for assessing drug–drug interactions involving hepatic drug transporters such as organic anion-transporting peptides (OATP), 1B1 and 1B3. Materials & methods: Plasma and urine extracts were analyzed for CP-I/CP-III using a TripleTOF API6600 mass spectrometer. Results:
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