Bioanalysis Zone

Assessing a multiplex targeted proteomics approach for the clinical diagnosis of periodontitis using saliva samples


Aim: The present study focused on the research of new biomarkers based on the liquid chromatography-multiple-reaction monitoring (MRM) proteomic profile in whole saliva of patients with periodontitis compared with periodontal healthy patients. Methods: A 30-min multiplexed liquid chromatography-MRM method was used for absolute quantification of 35 plasma biomarkers in saliva from control patients and patients with periodontitis. Results:

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Hear from the author, Christophe Hirtz, about this research in an exclusive author’s perspective interview, here.


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