Bioanalysis Zone

Validated UHPLC–MS/MS method for quantification of doxycycline in abdominal aortic aneurysm patients


Aim: There is a strong evidence that doxycycline can benefit abdominal aortic aneurysms patients because of its ability to inhibit matrix metalloproteinase enzymes. There is a need for a specific quantification method for doxycycline in these patients. We report herein the development and validation of a selective, specific, simple and rapid UHPLC–MS/MS method for doxycycline.

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