What is immunogenicity?

What is immunogenicity? Immunogenicity refers to the ability of a substance to trigger an adaptive immune response in the body. It is characterized by the presence of anti-drug antibodies (ADAs) — antibodies that bind to the idiotope of another antibody, protein, etc, in a patient or animal following biopharmaceutical administration. How does immunogenicity arise? Immunogenicity can arise from two main mechanisms. The first is T-cell dependent, while the second is T-cell independent. The T-cell-dependent pathway involves antigen-presenting cells that capture and internalize antigens. These antigens are then processed and displayed on the surface of antigen-presenting cells in association with MHC...