Bioanalysis Zone

Human microdosing for the prediction of patient response


“While it remains to be seen whether microdosing is a truly viable strategy for diagnostics, the approach has the potential to enable personalized medicine for the treatment of a variety of diseases…”

Microdosing allows study of the behavior of drugs via the administration of doses so low they are unlikely to produce whole-body effects, but of sufficient concentration to allow the determination of absorption, distribution, metabolism and excretion (ADME). Microdosing was recently reviewed elsewhere [1,2]; although most effort to date has focused on pharmacokinetic (PK) predictions to accelerate drug development, microdosing was born out of molecular toxicology research [3–10] and is now extending to medical diagnostics applications.

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