Arthur Moseley obtained his PhD from the University of North Carolina at Chapel Hill (NC, USA) under the direction of Jim Jorgenson, before moving on to GlaxoSmithKline (GSK), where he spent 16 years managing MS laboratories. From 1997 to 2006 he managed the proteomics MS laboratory at GSK’s Research Triangle Park (NC, USA). Moseley then served as the transnational manager of both the Research Triangle Park as well as GSK’s Stevenage site (UK) from 2001 to 2006. Arthur Moseley is currently the Director of the Proteomics and Metabolomics Core Facility at the Center for Genomic and Computational Biology at Duke University (NC, USA). His primary research interests are in the development and application of ultraperformance LC/LC/MS/MS systems for label-free differential expression proteomics and metabolomics, and the application of this technology to the qualitative and quantitative phenotypic characterization of cell lines, tissues, and biofluids.
Could you tell Bioanalysis Zone a little about your current role at the Duke Proteomics and Metabolomics Core Facility?
I came to Duke in 2007 to create a Proteomics Core Facility to provide protein characterization resources for the Duke Research Community. We designed the Facility with a scope of resources to support a diverse array of basic science studies, and the scale of resources to support clinical studies – including biomarker discovery and biomarker verification. In 2013, the Facility expanded its UPLC/MS/MS services to include qualitative and quantitative metabolite characterization. In recognition of this change, the Facility is now the Duke Proteomics and Metabolomics Facility. The Facility is staffed with seven scientists with a combined experience of nearly 90 years in the analysis of peptides, proteins, and small molecules by LC-MS/MS.
In addition to my role as Facility Director, I have an appointment as Associate Research Professor in the Department of Medicine, and I serve in two Centers: the Center for Genomic and Computational Biology (of which our Facility is a part), and in the Center for Applied Genomics and Precision Medicine. While the majority of our work supports the School of Medicine, our Facility extends across the university.
We support a diverse array of types of projects, most of which require quantitative analyses with high precision and accuracy. These studies include fundamental systems biology studies of plant and animal models, characterization of the functional molecular machines of life (protein complexes), and biomarker discovery and biomarker verification.