Original Publication Date: 1 January, 2018
Publication / Source: Bioanalysis 10(4)
Authors: Desvignes C, Passot C, Ternant D, Caulet M, Guerineau C, Lecomte T, Paintaud G
Aim: Panitumumab is a monoclonal antibody directed against EGFR that is approved for the treatment of metastatic colorectal cancer. To investigate its pharmacokinetics and concentration–response relationship, a validated assay is required.
Results: An ELISA assay was developed and validated according to international recommendations. Six calibrators (ranging from 0.1 to 20 mg/l) plus one anchor point (50 mg/l) and three
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