Bioanalysis Zone

Development of two complementary LC–HRMS methods for analyzing sotatercept in dried blood spots for doping controls

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The current routine sampling of blood specimens in sports drug testing faces major challenges ranging from temperature-controlled shipment and storage, limited stability and timely analysis [1] to the need of a phlebotomist for venous blood on-the-spot sampling. To overcome these limitations and increase the number of collected blood samples, the Word Anti-Doping Agency (WADA) pays particular attention to the use of alternative matrices such as dried blood spots (DBS) [2]. This straightforward alternative matrix uses a minimal volume (10–20 μl) of capillary blood collected by a finger, heel or ear prick on a cellulose paper and allows high-throughput and automation of sample processing and analysis [3–5]. Its almost 100-year history and wide range of applications is summarized elsewhere [6]. DBS cards stabilize many analytes, hence are suitable for establishing biobanks, which ensure very long storage times

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