Ultra-high sensitivity, expanded flexibility, increased stability and robustness – the Nexera X2 UHPLC system targets routine analysis and applications in highly regulated environments demanding complex system setups. System flexibility The system flexibility is based on software features which control multiple gradients in a single system. This enables automated solvent blending on each pump in a
Oasis® sample extraction product
The Oasis® family of solid-phase extraction products is designed to simplify and improve your sample preparation by combining the right sorbent chemistry, device format and methodology. Achieve robust, selective, and sensitive SPE methods without worrying about low recoveries caused by breakthrough of polar compounds, sorbent drying, pH limitations and undesirable silanol activity. Click here to
Ascentis® Express Products by Sigma-Aldrich: Columns used for seperation of peptides, amines and small proteins
Peptide ES-C18 HPLC Columns Ascentis® Express Peptide ES-C18 is a high-speed, high-performance liquid chromatography column based on a new 160Å Fused-Core® particle design. As such, Ascentis Express Peptide ES-C18 columns were specifically engineered to separate higher molecular weight compounds; peptides and small proteins for example. Their capacity for larger analytes and exceptional ruggedness make
ProteinWorks for large molecule quantification… Because Size Matters
Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach.
A Sub-2-µm Solid-Core Particle that Lives Up to Its Potential The latest addition to the Waters family of sub-2-µm UltraPerformance LC® Columns, CORTECS™ 1.6µm Columns deliver new levels of efficiency, resolution, and throughput. With this silica-based solid-core particle designed for UPLC you can better separate your analytes, process more samples in the same amount
The Sirocco™ Plates are the most technologically advanced protein precipitation plates in the market and enable high-throughput “in-well” protein precipitation of biological samples without the fear of cloudy filtrates or clogged devices. It also provides optimum performance in faster processing time by reducing steps in “in-well” sample processing and complete recovery of clean filtrate from smaller
World’s first system – Fully automated sample preparation module for LC-MS
Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS. The CLAM-2000* (Clinical Laboratory Automated sample preparation Module) automates the pretreatment of blood or other biological samples before LC-MS analysis. It is designed for customers handling blood samples in pharmaceutical departments, medical departments or biological analysis laboratories dealing with
Analysis of Anionic Metabolites – On-Demand Webinar
Ion chromatography coupled with high resolution accurate mass spectrometry (IC-HR/AM) using orbitrap MS technology provides the solution to many of the analytical challenges involved in differentiating isobaric metabolites. This on-demand webinar will discuss how IC-HR/AM provides superior chromatographic resolution to separate polar metabolites, superior resolution of polar isobaric metabolites, and superior sensitivity of polar metabolites.
Anti-hIgG Fc antibodies for generic PK assays
Bio-Rad offers two antibody clones specific to human IgG Fc that can be used to detect human or humanized therapeutic antibodies in non-human primate samples.
Mitra Microsampling Device – 20 µL cartridge
The Mitra® 20 µL Cartridge Microsampler, based on Volumetric Absorptive Microsampling (VAMS™) technology, accurately and reliably collects 20 µL of blood (or other biological fluid) in seconds, while eliminating the volumetric hematocrit bias typically associated with the dried blood spotting technique.
Nexera MX – Accelerates workflow and improves analytical efficiency
Shimadzu’s new Nexera MX ultra-fast multianalyte LC-MS system offers up to double the sample processing capability of the conventional approach.
Utilizing Novel SPME LC Tips for Forensic Screening of Drugs of Abuse in Urine Samples
The monitoring of drugs of abuse in biological matrices is a large and growing business for the laboratory testing industry. This article describes an innovative, 1-step, rapid microsampling and sample prep technique that is both selective and quantitative.
The Focus on Peptides is Growing
Analyzing peptides may be one of the greatest challenges the bioanalyst faces. At Waters we understand the subtleties affecting the development of robust, reliable, high sensitivity bioanalytical assays for peptides. We developed a Solution Guide with sample preparation protocols and separation conditions that will help you quickly and effectively develop methods for any peptide. To
Supel™-Select HLB SPE by Sigma-Aldrich
Supelco’s Supel-Select HLB SPE is a hydrophilic modified styrene based polymer developed for the solid phase extraction of a broad range of compounds from aqueous samples. The retention mechanism is predominately based on reversed-phase interaction. However, because the phase is hydrophilic modified, the phase is also selective for more polar compounds. Examples of more polar
Pass-Through Sample Preparation Product vs. SSLE vs. LLE
Which would you choose? Watch our latest 2 minute Ostro video and get ALL the facts. Watch now
Take the Complexity out of Protein Quantification with ProteinWorks
Reduce the Time to Results and Cost of Analysis with ProteinWorks™ Sample Preparation Kits, allowing you to achieve reproducible, sensitive, and standardized protein quantification.
The transition to biologics bioanalysis just became less daunting. Everything you need in one place: from packaged sample prep kits linked with lab automation to advanced LC-MS/MS systems and software, plus ready-to-use methods and consulting from application experts in biologics bioanalysis. Now you can fly up the biologics bioanalysis learning curve with less time investment
Antibodies against etanercept
Bio-Rad has developed antibodies against the biotherapeutic protein etanercept, including an antibody that is targeted to the TNFR2(p75)-IgGFc fusion region, enabling detection of etanercept very specifically. The antibodies are ideal for the development of a PK bridging ELISA, and as a reference standard in an ADA assay. They support bioanalytical and therapeutic drug monitoring assays for etanercept and biosimilar products.
Supelco′s Supel™-Select SPE
Supelco′s Supel™-Select SPE are hydrophilic modified styrene based polymers developed for the solid phase extraction of a broad range of compounds from aqueous samples. The retention mechanism for HLB is predominantly based on reversed-phase interaction. However, because the phase is hydrophilic modified, it is also selective for more polar compounds. The retention mechanism for SCX/SAX
Ascentis® Express Products: Fast HPLC Columns By Sigma-Aldrich
A Breakthrough in HPLC Column Performance Based on Fused-Core® Particle Technology, Ascentis Express HPLC columns offer significant performance benefits over popular columns based on totally porous particles. Ascentis Express columns based on 2.7 μm particles provide the high efficiency separation of sub-2-μm particles, but at higher speed and half of the backpressure. This lower pressure
Changes Everything – LCMS-8060 triple quadrupole mass spectrometer expands UFMS family
Shimadzu’s new LCMS-8060 is designed to push the limits of LC/MS/MS quantitation for applications requiring the highest sensitivity and robustness while delivering a meaningful solution for routine LC/MS/MS analyses. It detects substances at ultra-trace level as they occur in complex matrices, for example, or in smallest sample concentrations which have to be diluted in order
LC-MS Resource Guide: Consumables and Tips for Routine and Advanced LC-MS Performance
Maximize the performance of your LC-MS using proven consumables. Scientists deal with highly complex and variable sample matrices, analytes at vanishingly low concentrations, and pressure to keep analysis time to a minimum. The sample prep and chromatography components of their LC-MS workflow must be able to help them meet these challenges. In this brochure we
Sample preparation guide to fixing problems
Hang this complimentary Troubleshooting Poster in your laboratory or office for quick and handy references to fix problems fast. This attractive poster includes solutions to a multitude of Sample Preparation techniques including: Solid Phase Extraction (SPE), Solid-Liquid, QuEChERS, Liquid-Liquid, Modern Soxhlet and Supercritical fluid extraction.
Applications for Rapid Separations
Solve your UHPLC separation challenges faster and more effectively than ever before with the combination of the Thermo Scientific™ Accucore™ Vanquish UHPLC columns and the Vanquish UHPLC system. Learn More
A novel collection of stable isotope-labeled (SIL, or “heavy labeled”) full length proteins designed to be used as mass spectrometry internal standards for quantitative proteomics. The ideal method of optimizing reproducibility and accuracy in protein quantification by mass spectrometry is to add a full length SIL recombinant protein, equivalent to the native target protein, to
Thermo Scientific BioLC columns
Monoclonal antibody characterization treatment is amongst the most effective methods of diagnosis and treatment of a broad range of diseases. The challenge is to achieve accurate, high resolution results quickly. Thermo Scientific BioLC columns are designed with innovative packing to deliver unique separation capabilities to meet the wide variety of separation needs. For more information
Peptides and proteins are not small molecules. Why treat them the same?
Improved microfluidics for better sensitivity and reduced sample load Large molecule quantification is one of the greatest challenges that bioanalysts face. Sensitivity and specificity issues are numerous: fewer molecules per volume; limited recovery due to complex sample prep; increased fragmentation; and so on. The ionKey/MS™ System integrates UPLC analytical separation directly into the source of
Regulated Bioanalysis Platform Solution with UNIFI
Improve data quality and consistency of results with the most productive solution: the Waters Regulated Bioanalysis Platform Solution with UNIFI. Develop robust methods with sensitivity to meet assay requirements. Maximize up time and minimize cost per sample while complying with regulatory and analytical demands. Learn More Today
When a bioanalysis solution is needed to deliver the benefits of LC/MS/MS, the Waters Xevo TQ-S Mass Spectrometer delivers the ultimate in analytical performance. Achieve the lowest limits of detection with unprecedented levels of sensitivity, selectivity, and accuracy to quantify trace drugs and their metabolites. Learn More Today
ProteinWorks for Large Molecule Quantification…Because Size Matters
Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach. Download the NEW ProteinWorks Application Notebook Detailed applications covering: A standardized, streamlined approach
ACQUITY UPC² System
Many bioanalytical methods utilize liquid-liquid extraction (LLE) with non-polar solvents because LLE produces a cleaner extract.
Nexera UC fully automated SFE-SFC-MS
The Swiss Knife of analytics Shimadzu’s Nexera UC unified chromatography system is the world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC). The SFE/SFC/MS platform merges quick and easy online sample preparation with advanced chromatographic analysis and high sensitivity detection. The Nexera UC serves a wide range
Thermo Scientific SOLA SPE cartridges and plates – Technical Guide
SOLA products provide unparalleled performance characteristics compared to conventional SPE, phospholipid removal and protein precipitation products. This includes: • Higher levels of reproducibility • Higher levels of extract cleanliness • Reduced solvent requirements • Increased sensitivity. The manufacturing process has the additional benefit of removing extractables from component parts, resulting in cleaner sample extracts. SOLA
Mitra Microsampling – 10 µL and 20 µL Clamshells
The Mitra® Clamshell Microsamplers, based on Volumetric Absorptive Microsampling (VAMS™) technology, accurately and reliably collect 10 or 20 µL of blood (or other biological fluid) in seconds, while eliminating the volumetric hematocrit bias typically associated with the dried blood spotting technique.
Xevo G2-S QTof – Waters
Ultimate benchtop exact mass MS performance meets next-generation software processing to achieve the most comprehensive and accurate metabolite identification studies. Please click here to Download Technology Brief Metabolite Identification Overview An intelligent workflow that works as efficiently as you do. Great instrumentation is just the starting point for successful metabolite identification. What matters most is
Sciex: SelexION® differential mobility spectrometry
The SCIEX SelexION differential mobility spectrometry (DMS) device delivers highly-selective, robust and powerful ion separation that significantly enhances your quantitative performance. Designed to be simple to install without the need to break vacuum on your MS, and compatible with UHPLC timescales, this separation device can help you address your biggest analytical challenges
Thermo Scientific Q Exactive LC-MS/MS
Quanfirmation: Identify, Quantify & Confirm; High scan speed & multiplexing for broad screening and specific targeted approaches to identify, quantify and confirm.
COLUMNS FOR GLYCAN ANALYSIS
Waters now offers both UPLC and HPLC, BEH-based columns for analyzing labeled, N-linked glycans from biotherapeutic proteins. Each columns is QC tested with the 2AB labeled Waters Glycan Performance Standard to ensure batch-to-batch reproducibility and highly similar separated glycan profiles. Consequently, chromatographers can now choose the most appropriate LC-based technology to address their specific released
HILIC for large biomolecules
Hydrophillic Interaction Chromatography (HILIC) has been widely used to separate small polar compounds, yet its application to large biomolecules, other than released glycans, has been surprisingly limited. With the widepore Waters ACQUITY UPLC Glycoprotein BEH Amide 300Å, 1.7μm Column and some new ideas on separation methods, it is now possible to use HILIC to glean previously unattainable information from intact proteins (with or without glycosylation), protein fragments, and complex, released glycans.
The Advent of Bioanalytical Microsampling using Biocompatible SPME and Benefits over Dried Blood Spots There is growing interest in clinical and bioanalytical research fields toward microextraction or microsampling techniques for sample isolation, storage, and transportation. This interest comes from cost and ethics standpoints as researchers seek an inexpensive alternative to terminal blood draws. In
Thermo Scientific™ WebSeal™ system
The Thermo Scientific™ WebSeal™ system presents a range of well plates which meet the requirements of today´s chromatographer using well plate compatible autosamplers. The WebSeal system is a comprehensive range of polypropylene well plates and seals that can be used for different types of analytical challenges and various chromatographic applications. For more information click
Sigma-Aldrich: Phytopharma Standards
For the quality control of herbal medicinal products, reliable analytical standards are needed. Sigma-Aldrich offers an extensive range of analytical standards as well as several primary standards (qualified by quantitative NMR). For more information click here.
Sigma-Aldrich: Certified Reference Materials from Cerilliant ®
Cerilliant offers more than 3,000 catalog products including parents, metabolites, & stable-labeled internal standards for pharmaceutical, clinical research & diagnostic, clinical & forensic toxicology, natural products, and environmental industries. Cerilliant is accredited to ISO Guide 34 & ISO/IEC 17025 and certified to ISO 13485 & ISO 9001. Our quality system incorporates FDA′s GMP and GLP
Prominence Inert LC System
Prominence Inert LC system, a metal-free instrument ideal for analyzing aggregates or other biological macromolecules in biopharmaceuticals.
Oasis PRiME HLB
Are Sample Matrices Causing Bad Effects in your MS Analyses? Don’t just suffer – Deal with them using Oasis PRiME HLB!
World’s first system – Fully automated sample preparation module for LC-MS
Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS.
Using Tof MRM, Target Enhancement and Ion Mobility for Quantitation using a Time-of-Flight Mass Spectrometer
Poster illustrates benefits of Tof-MRM. Scenarios extend full scan HRMS approaches. Key conclusions: · Additional 2-5 fold sensitivity increase for small molecule drugs in plasma · Simplifies analysis for assays with maximum sensitivity quantitative end points · Traveling wave ion mobility with dynamic range enhancement is currently in development to provide additional quantitative capabilities Download
Biosimilar antibodies for research use
To enable fast and inexpensive assay development, Bio-Rad has introduced five biosimilars of monoclonal antibody drugs for research use, complementing our most popular anti-biotherapeutic antibodies
Trace level quantitation of multiple compounds
Shimadzu’s LCMS-8050 triple quadrupole LC-MS/MS meets the growing demand for trace-level quantitation in clinical research and other markets. It incorporates proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As the flagship model of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high sensitivity, high data quality