Ascentis® Express Products by Sigma-Aldrich: Columns that use combined technology

Phenyl-Hexyl HPLC Columns The phenyl phase has unique reversed-phase selectivity, especially for polar aromatics and heterocyclic compounds, arising from solute interaction with the aromatic ring and its delocalized electrons. Ascentis® Express Phenyl-Hexyl is complementary (orthogonal) to both C18 and RP-Amide Ascentis Express phases because of this unique aromaticity. Phenyl phases also tend to exhibit good

Sample preparation guide to fixing problems

Hang this complimentary Troubleshooting Poster in your laboratory or office for quick and handy references to fix problems fast. This attractive poster includes solutions to a multitude of Sample Preparation techniques including: Solid Phase Extraction (SPE), Solid-Liquid, QuEChERS, Liquid-Liquid, Modern Soxhlet and Supercritical fluid extraction.

Oasis® sample extraction product

The Oasis® family of solid-phase extraction products is designed to simplify and improve your sample preparation by combining the right sorbent chemistry, device format and methodology. Achieve robust, selective, and sensitive SPE methods without worrying about low recoveries caused by breakthrough of polar compounds, sorbent drying, pH limitations and undesirable silanol activity. Click here to

Ascentis® Express Products by Sigma-Aldrich: Columns for starting a new method and lipid analysis

C18 HPLC Column   Ascentis® Express C18 is the first choice for starting a new method. Ascentis Express HPLC columns, through the use of Fused-Core® particle technology, can provide you with both the high speed and high efficiencies of sub-2 μm particles at lower system pressure. With identical conditions, the Ascentis Express C18 column performs

Bioanalysis Zone Spotlight on Antibody-Drug Conjugates (ADCs)

With the potential to allow targeted delivery of anticancer drugs to tumors, with minimal impact on normal tissue, there is increasing interest in ADCs in new drug development. The heterogeneity and dynamic nature of ADCs raises unique bioanalytical challenges, which Waters explores in Bioanalysis Zone’s Spotlight on ADCs. Learn how these challenges can be addressed


Trace level quantitation of multiple compounds Shimadzu’s LCMS-8050 triple quadrupole LC-MS/MS meets the growing demand for trace-level quantitation in clinical research and other markets. It incorporates proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As one highlight of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high

Applications for Rapid Separations

Solve your UHPLC separation challenges faster and more effectively than ever before with the combination of the Thermo Scientific™ Accucore™ Vanquish UHPLC columns and the Vanquish UHPLC system. Learn More

ProteinWorks for Large Molecule Quantification…Because Size Matters

Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach. Download the NEW ProteinWorks Application Notebook Detailed applications covering: A standardized, streamlined approach

Ascentis® Express Products by Sigma-Aldrich: Columns used for seperation of peptides, amines and small proteins

Peptide ES-C18 HPLC Columns   Ascentis® Express Peptide ES-C18 is a high-speed, high-performance liquid chromatography column based on a new 160Å Fused-Core® particle design. As such, Ascentis Express Peptide ES-C18 columns were specifically engineered to separate higher molecular weight compounds; peptides and small proteins for example. Their capacity for larger analytes and exceptional ruggedness make

Thermo Scientific BioLC columns

Monoclonal antibody characterization treatment is amongst the most effective methods of diagnosis and treatment of a broad range of diseases. The challenge is to achieve accurate, high resolution results quickly. Thermo Scientific BioLC columns are designed with innovative packing to deliver unique separation capabilities to meet the wide variety of separation needs. For more information

Agilent Captiva Filtration

Captiva’s unique dual-depth filtration media provides complete removal of precipitated proteins and outstanding resistance to sample clogging, with no loss of analytes. All Captiva components are ultra clean, and rigorously tested to ensure against non-specific binding. With Captiva, your plasma samples are processed quickly and reliably. Captiva is easily automated for enhanced productivity and excellent

Exploring Extra Sensitivity for Analysis in Human Plasma

The need for unambiguous data to support milestone transition and compound selection for drug discovery and development has fueled an unrelenting desire for instruments with higher sensitivity. In this study, we analyze a variety of drugs in human plasma using ionKey/MS. Download application note

Thermo Scientific Q Exactive LC-MS/MS

Quanfirmation: Identify, Quantify & Confirm; High scan speed & multiplexing for broad screening and specific targeted approaches to identify, quantify and confirm.

Take the Complexity out of Protein Quantification with ProteinWorks

Reduce the Time to Results and Cost of Analysis with ProteinWorks™ Sample Preparation Kits, allowing you to achieve reproducible, sensitive, and standardized protein quantification.

Supelco HPLC Accessories

Maximize the performance of your HPLC system View our new HPLC Accessories brochure, which contains a select group of products and recommendations to maximize the performance of your HPLC system. SupelConnect High Performance Fittings Upchurch Scientific Fittings and Accessories Optimize Technologies HPLC Dispersion Measurement PEEK HPLC Fittings Stainless Steel HPLC Fittings Inlet Line Filters Back-Pressure

Vials for Mass Spectrometry by Sigma-Aldrich

The chemist spends a great deal of energy, money and precious time on sample preparation. After that, the last thing a chemist needs is for the sample vials to contribute to contamination that may result in complicated data interpretion or complete reanalysis. By using vials certified to be nearly contaminant free the chemist can reduce

Ostro™ – Waters

Ostro™ 96-Well Plate provides a novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented in order to optimize your laboratory’s workflow. For more information click here

Agilent Bond Elut

For over 30 years, Bond Elut has been the most trusted name in solid phase extraction. Years of use by demanding chemists at top companies worldwide have thoroughly documented its many applications and proven its performance. To this day, you will find more literature references for Bond Elut than any other SPE product in the

The Focus on Peptides is Growing

Analyzing peptides may be one of the greatest challenges the bioanalyst faces. At Waters we understand the subtleties affecting the development of robust, reliable, high sensitivity bioanalytical assays for peptides. We developed a Solution Guide with sample preparation protocols and separation conditions that will help you quickly and effectively develop methods for any peptide. To

Anti-hIgG Fc antibodies for generic PK assays

Bio-Rad offers two antibody clones specific to human IgG Fc that can be used to detect human or humanized therapeutic antibodies in non-human primate samples.


Waters now offers both UPLC and HPLC, BEH-based columns for analyzing labeled, N-linked glycans from biotherapeutic proteins. Each columns is QC tested with the 2AB labeled Waters Glycan Performance Standard to ensure batch-to-batch reproducibility and highly similar separated glycan profiles. Consequently, chromatographers can now choose the most appropriate LC-based technology to address their specific released

Xevo G2-S QTof – Waters

Ultimate benchtop exact mass MS performance meets next-generation software processing to achieve the most comprehensive and accurate metabolite identification studies. Please click here to Download Technology Brief Metabolite Identification Overview An intelligent workflow that works as efficiently as you do. Great instrumentation is just the starting point for successful metabolite identification. What matters most is


5 Steps too Many? The time has come to make sample prep simpler… Coming In June see it in PRiME time. Get PRiMED

Biosimilar antibodies for research use

To enable fast and inexpensive assay development, Bio-Rad has introduced five biosimilars of monoclonal antibody drugs for research use, complementing our most popular anti-biotherapeutic antibodies

Thermo Scientific TSQ Vantage

Thermo Scientific* TSQ Vantage triple stage quadrupole mass spectrometer delivers the highest sensitivity with the lowest noise for the quantitative analysis of small molecules, peptides, biosimilars, and biologics. More signal and less noise provides better assay precision and accuracy. Combined with a robust new ion source, second generation (G2) ion optics and hyperbolic quadrupoles, the

Advantages of Ostro Pass-through Sample Preparation Versus Solid Supported Liquid Extraction (SSLE)

Which would you choose? Read the latest Application note from Waters and get ALL the facts. Learn More

Phree Phospholipid Removal Solutions

Phree Phospholipid Removal Solutions offer a fast effective way to remove proteins and phospholipids from plasma samples without negatively affecting the recovery of your target analytes. The Solvent Shielding Technology™ design of the Phree Phospholipid Removal products will withhold organic solvents above the filter membranes for up to 25 minutes, allowing for direct in-well or

Sigma-Aldrich: Certified Reference Materials from Cerilliant ®

Cerilliant offers more than 3,000 catalog products including parents, metabolites, & stable-labeled internal standards for pharmaceutical, clinical research & diagnostic, clinical & forensic toxicology, natural products, and environmental industries. Cerilliant is accredited to ISO Guide 34 & ISO/IEC 17025 and certified to ISO 13485 & ISO 9001. Our quality system incorporates FDA′s GMP and GLP

Antibodies against etanercept

Bio-Rad has developed antibodies against the biotherapeutic protein etanercept, including an antibody that is targeted to the TNFR2(p75)-IgGFc fusion region, enabling detection of etanercept very specifically. The antibodies are ideal for the development of a PK bridging ELISA, and as a reference standard in an ADA assay. They support bioanalytical and therapeutic drug monitoring assays for etanercept and biosimilar products.

New Application Note from Waters

Learn how you can reduce processing times and overall cost by using a Simplified Solid Phase Extraction (SPE) 3-step protocol for bioanalysis using Oasis HLB. Get the facts


A novel collection of stable isotope-labeled (SIL, or “heavy labeled”) full length proteins designed to be used as mass spectrometry internal standards for quantitative proteomics. The ideal method of optimizing reproducibility and accuracy in protein quantification by mass spectrometry is to add a full length SIL recombinant protein, equivalent to the native target protein, to

Regulated Bioanalysis Platform Solution with UNIFI

Improve data quality and consistency of results with the most productive solution: the Waters Regulated Bioanalysis Platform Solution with UNIFI. Develop robust methods with sensitivity to meet assay requirements. Maximize up time and minimize cost per sample while complying with regulatory and analytical demands. Learn More Today

Greater simplicity and reliability in the determination of amino acid sequences

For amino acid sequences, the PPSQ 51A / 53 A protein sequencer series and the LabSolutions PPSQ software create user benefits leading to greater simplicity and reliability combined with FDA compliance.

The Move to Biologics Bioanalysis is Easier Than You Think

The move to large molecules in Pharma is accelerating, but for those with extensive experience with small molecule bioanalysis, the shift to biologics can be challenging. The BioBA Solution enables you go from samples to data with confidence. Everything you need in one place: from packaged sample prep kits linked with lab automation to advanced

Phenomenex Product Guide 2014/ 2015

Phenomenex Releases Updated Product Guide for 2014/2015  in Print and Digital Formats Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the publication of its updated product and services guide for 2014/2015. Covering the company’s comprehensive lines of HPLC/UHPLC Columns, GC Columns, and SFC columns and

Thermo Scientific™ WebSeal™ system

  The Thermo Scientific™ WebSeal™ system presents a range of well plates which meet the requirements of today´s chromatographer using well plate compatible autosamplers. The WebSeal system is a comprehensive range of polypropylene well plates and seals that can be used for different types of analytical challenges and various chromatographic applications. For more information click

Anti-Idiotypic Antibodies for Pharmacokinetic Assays

Anti-idiotypic antibodies can be generated to bind specifically to one monoclonal antibody drug. These highly specialized antibodies can be used to set up pharmacokinetic (PK) assays in different formats to measure free or total drug levels in preclinical and clinical samples. Bio-Rad has developed highly specific, high affinity anti-biotherapeutic antibodies to support preclinical research, clinical

ProteinWorks for large molecule quantification… Because Size Matters

Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach.

HILIC for large biomolecules

Hydrophillic Interaction Chromatography (HILIC) has been widely used to separate small polar compounds, yet its application to large biomolecules, other than released glycans, has been surprisingly limited. With the widepore Waters ACQUITY UPLC Glycoprotein BEH Amide 300Å, 1.7μm Column and some new ideas on separation methods, it is now possible to use HILIC to glean previously unattainable information from intact proteins (with or without glycosylation), protein fragments, and complex, released glycans.

Nexera X2 – X-ceptional insights

Ultra-high sensitivity, expanded flexibility, increased stability and robustness – the Nexera X2 UHPLC system targets routine analysis and applications in highly regulated environments demanding complex system setups. System flexibility The system flexibility is based on software features which control multiple gradients in a single system. This enables automated solvent blending on each pump in a

Nexera X2 – X-ceptional insights

Ultra-high sensitivity, expanded flexibility, increased stability and robustness – the Nexera X2 UHPLC system targets routine analysis and applications in highly regulated environments demanding complex system setups. System flexibility The system flexibility is based on software features which control multiple gradients in a single system. This enables automated solvent blending on each pump in a

SILu™MAb Infliximab

SILu™MAb Infliximab(MSQC9) is a recombinant, stable isotope-labeled, monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, it is designed to be used as an internal standard for the quantitative mass spectrometry analysis of Infliximab in human serum. Infliximab is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor

Introducing Oasis PRiME HLB!

Using ³good enough² sample preparation approaches that fail to adequately prepare samples can lead to shortened column lifetimes as well as poor method sensitivity and precision due to ion suppression or enhancement. To overcome these issues, Waters has developed a new, easy-to-use, streamlined approach, based on a water-wettable, reversed-phase sorbent that produces high recoveries, improved

Supelco′s Supel™-Select SPE

Supelco′s Supel™-Select SPE are hydrophilic modified styrene based polymers developed for the solid phase extraction of a broad range of compounds from aqueous samples. The retention mechanism for HLB is predominantly based on reversed-phase interaction. However, because the phase is hydrophilic modified, it is also selective for more polar compounds. The retention mechanism for SCX/SAX

Thermo Scientific™ Virtuoso™ Vial Identification System

Expect more… Accuracy, reliability and productivity The Thermo Scientific™ Virtuoso™ Vial Identification System imprints customizable information DIRECTLY onto Thermo Scientific vials. The system provides an error-free solution to vial labeling while the overall quality of the data ensures reliable vial identification.  Virtuoso is a first of its kind system that provides accuracy, legibility and higher

Waters ionKey/MS System

The robustness and reliability of pharmacokinetic (PK) data is an essential part of bioanalysis. LC/MS is the technique of choice in quantitative bioanalysis due to its high selectivity and sensitivity. The use of reduced-bore chromatographic columns dimensions such as 180-300 µm I.D. for the analysis of biological fluids can be traced back to the late

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