Waters CORTECS 2.7 µm Solid-Core Particle Columns have arrived!

CORTECS® 2.7 µm Columns are designed to heighten performance of existing LC system and maximize efficiency at HPLC-optimized backpressures. This pressure advantage without an efficiency trade off, provides the flexibility to run methods using longer column lengths for improved resolution or higher flow rates to speed analysis and increase throughput. Find out more click here

Advantages of Ostro Pass-through Sample Preparation Versus Solid Supported Liquid Extraction (SSLE)

Which would you choose? Read the latest Application note from Waters and get ALL the facts. Learn More

Ostro™ – Waters

Ostro™ 96-Well Plate provides a novel solution for the cleanup of phospholipids in plasma and serum. Requiring minimal to no method development and using a simple protocol, this technology can be quickly implemented in order to optimize your laboratory’s workflow. For more information click here

Thermo Scientific TSQ Module

Current bioanalytical LC-MS/MS workflows require the use of multiple software packages to track samples, acquire and process data, create reports and archive studies. Until now, no LIMS managed the bioanalytical workflow from beginning to end. With Watson LIMS and the TSQ Module working together, data from the entire bioanalytical workflow can reside in a single

Phree Phospholipid Removal Solutions

Phree Phospholipid Removal Solutions offer a fast effective way to remove proteins and phospholipids from plasma samples without negatively affecting the recovery of your target analytes. The Solvent Shielding Technology™ design of the Phree Phospholipid Removal products will withhold organic solvents above the filter membranes for up to 25 minutes, allowing for direct in-well or

Ascentis® Express Products: Fast HPLC Columns By Sigma-Aldrich

A Breakthrough in HPLC Column Performance Based on Fused-Core® Particle Technology, Ascentis Express HPLC columns offer significant performance benefits over popular columns based on totally porous particles. Ascentis Express columns based on 2.7 μm particles provide the high efficiency separation of sub-2-μm particles, but at higher speed and half of the backpressure. This lower pressure

Using Tof MRM, Target Enhancement and Ion Mobility for Quantitation using a Time-of-Flight Mass Spectrometer

Poster illustrates benefits of Tof-MRM. Scenarios extend full scan HRMS approaches. Key conclusions: ·  Additional 2-5 fold sensitivity increase for small molecule drugs in plasma ·  Simplifies analysis for assays with maximum sensitivity quantitative end points ·  Traveling wave ion mobility with dynamic range enhancement is currently in development to provide additional quantitative capabilities Download

Thermo Scientific Q Exactive LC-MS/MS

Quanfirmation: Identify, Quantify & Confirm; High scan speed & multiplexing for broad screening and specific targeted approaches to identify, quantify and confirm.

New Application Note from Waters

Learn how you can reduce processing times and overall cost by using a Simplified Solid Phase Extraction (SPE) 3-step protocol for bioanalysis using Oasis HLB. Get the facts

Xevo G2-S QTof – Waters

Ultimate benchtop exact mass MS performance meets next-generation software processing to achieve the most comprehensive and accurate metabolite identification studies. Please click here to Download Technology Brief Metabolite Identification Overview An intelligent workflow that works as efficiently as you do. Great instrumentation is just the starting point for successful metabolite identification. What matters most is

World’s first system – Fully automated sample preparation module for LC-MS

Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS. The CLAM-2000* (Clinical Laboratory Automated sample preparation Module) automates the pretreatment of blood or other biological samples before LC-MS analysis. It is designed for customers handling blood samples in pharmaceutical departments, medical departments or biological analysis laboratories dealing with

Sigma-Aldrich: Phytopharma Standards

For the quality control of herbal medicinal products, reliable analytical standards are needed. Sigma-Aldrich offers an extensive range of analytical standards as well as several primary standards (qualified by quantitative NMR). For more information click here.

World’s first system – Fully automated sample preparation module for LC-MS

Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS.

2 new app notes show how HRMS facilitates sensitivity increases for pharmaceutical analysis in human plasma

In the first study, we determine and compare the quantification attributes of detection limit (LOD), quantification limit (LOQ), and linear dynamic range for three data-acquisition modes: full-scan MS, MS,E and Tof-MRM.  In the presence of human plasma, the Tof-MRM mode of data acquisition can achieve on-column limits of detection that are in the low-femtogram range.

Supelco HPLC Accessories

Maximize the performance of your HPLC system View our new HPLC Accessories brochure, which contains a select group of products and recommendations to maximize the performance of your HPLC system. SupelConnect High Performance Fittings Upchurch Scientific Fittings and Accessories Optimize Technologies HPLC Dispersion Measurement PEEK HPLC Fittings Stainless Steel HPLC Fittings Inlet Line Filters Back-Pressure

SigmaMAb ADC Mimic

The SigmaMAb Antibody Drug Conjugate (ADC) Mimic, the newest addition to the SILu™MAb collection, is a non-toxic drug mimic that is utilized as a standard for mass spectrometry and high performance liquid chromatography. The ADC Mimic is SigmaMAb (MSQC4), an IgG1 monoclonal antibody, conjugated to dansyl fluorophores via a LC-SMCC crosslinker. This dansyl-LC-SMCC attachment serves

ProteinWorks for Large Molecule Quantification…Because Size Matters

Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach. Download the NEW ProteinWorks Application Notebook Detailed applications covering: A standardized, streamlined approach

Thermo Scientific SOLA – New WCX & WAX Phases for Bioanalysis

The mixed mode weak cation (WCX) and mixed mode weak anion (WAX) phases complement existing selectivity options by providing solutions to an even wider range of application areas. SOLA’s unique design allows for unparalleled performance characteristics and provides increased confidence in results when first time success within the bioanalytical and clinical research workflow is critical.

Applications for Rapid Separations

Solve your UHPLC separation challenges faster and more effectively than ever before with the combination of the Thermo Scientific™ Accucore™ Vanquish UHPLC columns and the Vanquish UHPLC system. Learn More

Sigma-Aldrich Low Adsorption (LA) – Vials Neutral pH

Features and Benefits: Maintains sample integrity during storage Minimizes pH shifts in the sample Reduces metal contamination in the sample Compatible with most autosamplers. Supelco′s new certified low adsorption CD, MRQ30 and QsertVial products now offer the benefit of maximum sample extraction without the worry of trace analytes being adsorbed by the vial surface. These

Aeris HPLC/ UHPLC Columns

Core-Shell Technology for Proteins and Peptides. Ultra-High Resolution and Performance on HPLC and UHPLC Systems

Introducing Oasis PRiME HLB!

Using ³good enough² sample preparation approaches that fail to adequately prepare samples can lead to shortened column lifetimes as well as poor method sensitivity and precision due to ion suppression or enhancement. To overcome these issues, Waters has developed a new, easy-to-use, streamlined approach, based on a water-wettable, reversed-phase sorbent that produces high recoveries, improved

Agilent Captiva Filtration

Captiva’s unique dual-depth filtration media provides complete removal of precipitated proteins and outstanding resistance to sample clogging, with no loss of analytes. All Captiva components are ultra clean, and rigorously tested to ensure against non-specific binding. With Captiva, your plasma samples are processed quickly and reliably. Captiva is easily automated for enhanced productivity and excellent

Thermo Scientific TSQ Vantage

Thermo Scientific* TSQ Vantage triple stage quadrupole mass spectrometer delivers the highest sensitivity with the lowest noise for the quantitative analysis of small molecules, peptides, biosimilars, and biologics. More signal and less noise provides better assay precision and accuracy. Combined with a robust new ion source, second generation (G2) ion optics and hyperbolic quadrupoles, the

Phenomenex Product Guide 2014/ 2015

Phenomenex Releases Updated Product Guide for 2014/2015  in Print and Digital Formats Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the publication of its updated product and services guide for 2014/2015. Covering the company’s comprehensive lines of HPLC/UHPLC Columns, GC Columns, and SFC columns and

The Move to Biologics Bioanalysis is Easier Than You Think

The move to large molecules in Pharma is accelerating, but for those with extensive experience with small molecule bioanalysis, the shift to biologics can be challenging. The BioBA Solution enables you go from samples to data with confidence. Everything you need in one place: from packaged sample prep kits linked with lab automation to advanced

HILIC for large biomolecules

Hydrophillic Interaction Chromatography (HILIC) has been widely used to separate small polar compounds, yet its application to large biomolecules, other than released glycans, has been surprisingly limited. With the widepore Waters ACQUITY UPLC Glycoprotein BEH Amide 300Å, 1.7μm Column and some new ideas on separation methods, it is now possible to use HILIC to glean previously unattainable information from intact proteins (with or without glycosylation), protein fragments, and complex, released glycans.

Prominence Inert LC System

Prominence Inert LC system, a metal-free instrument ideal for analyzing aggregates or other biological macromolecules in biopharmaceuticals.

Mitra Microsampling – 10 µL and 20 µL Clamshells

The Mitra® Clamshell Microsamplers, based on Volumetric Absorptive Microsampling (VAMS™) technology, accurately and reliably collect 10 or 20 µL of blood (or other biological fluid) in seconds, while eliminating the volumetric hematocrit bias typically associated with the dried blood spotting technique.

Pass-Through Sample Preparation Product vs. SSLE vs. LLE

Which would you choose? Watch our latest 2 minute Ostro video and get ALL the facts. Watch now

Nexera UC fully automated SFE-SFC-MS

The Swiss Knife of analytics Shimadzu’s Nexera UC unified chromatography system is the world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC). The SFE/SFC/MS platform merges quick and easy online sample preparation with advanced chromatographic analysis and high sensitivity detection. The Nexera UC serves a wide range

SPME LC (BioSPME) Tips and Probes by Sigma-Aldrich

SPME LC (BioSPME) Tips provide rapid 1-step sample handling prior to bioanalytical LC/MS or Direct MS.

Nexera MX – Accelerates workflow and improves analytical efficiency

Shimadzu’s new Nexera MX ultra-fast multianalyte LC-MS system offers up to double the sample processing capability of the conventional approach.

ProteinWorks for Large Molecule Quantification…Because Size Matters

Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks

Orthogonal choice to RPLC in bioanalysis – Waters

UltraPerformance Convergence Chromatography (UPC2) offers an orthogonal choice to reversed phase liquid chromatography (RPLC) in DMPK applications, particularly in quantitative assays for bioanalysis. Also well-suited for solvents used in sample preparation, UPC2 is compatible with solvents used for sample preparation, eliminating the need for evaporation and reconstitution typically needed for RPLC. For more information click

Nexera X2 – X-ceptional insights

Ultra-high sensitivity, expanded flexibility, increased stability and robustness – the Nexera X2 UHPLC system targets routine analysis and applications in highly regulated environments demanding complex system setups. System flexibility The system flexibility is based on software features which control multiple gradients in a single system. This enables automated solvent blending on each pump in a

Thermo Scientific BioLC columns

Monoclonal antibody characterization treatment is amongst the most effective methods of diagnosis and treatment of a broad range of diseases. The challenge is to achieve accurate, high resolution results quickly. Thermo Scientific BioLC columns are designed with innovative packing to deliver unique separation capabilities to meet the wide variety of separation needs. For more information

Ascentis® Express Products by Sigma-Aldrich: Columns used for seperation of peptides, amines and small proteins

Peptide ES-C18 HPLC Columns   Ascentis® Express Peptide ES-C18 is a high-speed, high-performance liquid chromatography column based on a new 160Å Fused-Core® particle design. As such, Ascentis Express Peptide ES-C18 columns were specifically engineered to separate higher molecular weight compounds; peptides and small proteins for example. Their capacity for larger analytes and exceptional ruggedness make


Stable Isotope-Labeled Universal Monoclonal Antibody (SILu™MAb) is a critical tool for the assessment of pharmacokinetic properties of biotherapeutics. SILu™MAb is a highly purified, stable isotope-labeled IgG monoclonal antibody (expressed in a proprietary Sigma-Aldrich CHO cell line) that utilizes universal heavy-labeled tryptic peptides as internal standards for the quantitation of monoclonal antibodies and Fc-fusion therapeutics. As

Peptides and proteins are not small molecules. Why treat them the same?

Wide mass range, reliable sensitivity Large molecule quantification is one of the greatest challenges that bioanalysts face. Sensitivity and specificity issues are numerous: fewer molecules per volume; limited recovery due to complex sample prep; increased fragmentation; and so on. A quantitative mass spec with a wide mass range is essential. With a built-in mass range


5 Steps too Many? The time has come to make sample prep simpler… Coming In June see it in PRiME time. Get PRiMED

Complimentary Poster: A Guide to SPE Method Optimization and Increasing your MS Sensitivity

Hang this complimentary Troubleshooting Poster in your laboratory or office for handy references to quickly and easily stream line your method. This attractive poster includes references to phase selection, starting /optimizing a method and mixed mode ion-exchange method optimization. Complimentary poster mailed to you Quick and handy references on method optimization Learn how to increase

Waters ionKey/MS System

The robustness and reliability of pharmacokinetic (PK) data is an essential part of bioanalysis. LC/MS is the technique of choice in quantitative bioanalysis due to its high selectivity and sensitivity. The use of reduced-bore chromatographic columns dimensions such as 180-300 µm I.D. for the analysis of biological fluids can be traced back to the late

Utilizing Novel SPME LC Tips for Forensic Screening of Drugs of Abuse in Urine Samples

The monitoring of drugs of abuse in biological matrices is a large and growing business for the laboratory testing industry. This article describes an innovative, 1-step, rapid microsampling and sample prep technique that is both selective and quantitative.

Titan™ UHPLC Columns from Supelco

  Based on 1.9 µm totally porous monodisperse silica, these columns provide the leading edge performance scientists expect (typically > 250,000 N/m), but at a greatly reduced cost. A limited number of Titan columns are available for evaluation, at no charge. Submit an evaluation request! Titan UHPLC columns, based on 1.9 µm totally porous monodisperse

Bioanalysis: The Analysis of Compounds in Biological Matrices, Sigma-Aldrich

Maximize the Speed & Sensitivity of Bioanalytical Assays Sample prep and analysis of bioanalytical samples can be a challenge, whether in DMPK/ADME in pharmaceutical drug discovery, clinical diagnostics and therapeutic drug monitoring in hospitals, testing for forensics and toxicology, metabolomics, or basic biochemical research. Although each application has its unique set of analytes, matrices, and

Antibodies against etanercept

Bio-Rad has developed antibodies against the biotherapeutic protein etanercept, including an antibody that is targeted to the TNFR2(p75)-IgGFc fusion region, enabling detection of etanercept very specifically. The antibodies are ideal for the development of a PK bridging ELISA, and as a reference standard in an ADA assay. They support bioanalytical and therapeutic drug monitoring assays for etanercept and biosimilar products.

Peptides and proteins are not small molecules. Why treat them the same?

Improved microfluidics for better sensitivity and reduced sample load Large molecule quantification is one of the greatest challenges that bioanalysts face. Sensitivity and specificity issues are numerous: fewer molecules per volume; limited recovery due to complex sample prep; increased fragmentation; and so on. The ionKey/MS™ System integrates UPLC analytical separation directly into the source of

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