Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS. The CLAM-2000* (Clinical Laboratory Automated sample preparation Module) automates the pretreatment of blood or other biological samples before LC-MS analysis. It is designed for customers handling blood samples in pharmaceutical departments, medical departments or biological analysis laboratories dealing with issues of variability in analytical results or infection risk. It is compatible with the LC-MS TQ systems LCMS-8040, LCMS-8045, LCMS-8050 and LCMS-8060, giving a large choice to adapt to sensitivity needs.
Ascentis® Express Products by Sigma-Aldrich: Columns used for seperation of peptides, amines and small proteins
Peptide ES-C18 HPLC Columns Ascentis® Express Peptide ES-C18 is a high-speed, high-performance liquid chromatography column based on a new 160Å Fused-Core® particle design. As such, Ascentis Express Peptide ES-C18 columns were specifically engineered to separate higher molecular weight compounds; peptides and small proteins for example. Their capacity for larger analytes and exceptional ruggedness make
Anti-Idiotypic Antibodies for Anti-Drug Antibody Assays
Anti-idiotypic antibodies can be generated to bind specifically to one monoclonal antibody drug and neutralize its activity. A well-designed anti-drug antibody (ADA) assay requires a highly specific reference antibody against which to measure an anti-drug response. For the clinical phases of development it should ideally be one or more fully human antibodies with varying affinities
Supelco′s Supel™-Select SPE
Supelco′s Supel™-Select SPE are hydrophilic modified styrene based polymers developed for the solid phase extraction of a broad range of compounds from aqueous samples. The retention mechanism for HLB is predominantly based on reversed-phase interaction. However, because the phase is hydrophilic modified, it is also selective for more polar compounds. The retention mechanism for SCX/SAX
COLUMNS FOR GLYCAN ANALYSIS
Waters now offers both UPLC and HPLC, BEH-based columns for analyzing labeled, N-linked glycans from biotherapeutic proteins. Each columns is QC tested with the 2AB labeled Waters Glycan Performance Standard to ensure batch-to-batch reproducibility and highly similar separated glycan profiles. Consequently, chromatographers can now choose the most appropriate LC-based technology to address their specific released
When a bioanalysis solution is needed to deliver the benefits of LC/MS/MS, the Waters Xevo TQ-S Mass Spectrometer delivers the ultimate in analytical performance. Achieve the lowest limits of detection with unprecedented levels of sensitivity, selectivity, and accuracy to quantify trace drugs and their metabolites. Learn More Today
ProteinWorks for large molecule quantification… Because Size Matters
Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks, Waters new family of protein bioanalysis sample preparation kits. ProteinWorks Kits simplify and accelerate protein digestion, streamlining and standardizing the traditionally complex pre-analytic workflow for LC-MS protein quantification via the surrogate peptide approach.
Trace level quantitation of multiple compounds Shimadzu’s LCMS-8050 triple quadrupole LC-MS/MS meets the growing demand for trace-level quantitation in clinical research and other markets. It incorporates proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As one highlight of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high
Mitra Microsampling – 10 µL and 20 µL Clamshells
The Mitra® Clamshell Microsamplers, based on Volumetric Absorptive Microsampling (VAMS™) technology, accurately and reliably collect 10 or 20 µL of blood (or other biological fluid) in seconds, while eliminating the volumetric hematocrit bias typically associated with the dried blood spotting technique.
ProteinWorks for Large Molecule Quantification…..Because Size Matters
Introducing ProteinWorks Sample Preparation Kits, allowing you to achieve reproducible, sensitive, and standardized protein quantification. Click here to view more
Stable Isotope-Labeled Universal Monoclonal Antibody (SILu™MAb) is a critical tool for the assessment of pharmacokinetic properties of biotherapeutics. SILu™MAb is a highly purified, stable isotope-labeled IgG monoclonal antibody (expressed in a proprietary Sigma-Aldrich CHO cell line) that utilizes universal heavy-labeled tryptic peptides as internal standards for the quantitation of monoclonal antibodies and Fc-fusion therapeutics. As
Thermo Scientific SOLA products
Thermo Scientific™ SOLA™ products revolutionize Solid Phase Extraction (SPE). This first fritless SPE product range provides greater reproducibility with cleaner, more consistent extracts. SOLA products provide unparalleled performance characteristics compared to conventional SPE, phospholipid removal and protein precipitation products. What this means to your analysis: Higher levels of reproducibility Higher levels of extract cleanliness Reduced
Advantages of Ostro Pass-through Sample Preparation Versus Solid Supported Liquid Extraction (SSLE)
Which would you choose? Read the latest Application note from Waters and get ALL the facts. Learn More
Oasis® sample extraction product
The Oasis® family of solid-phase extraction products is designed to simplify and improve your sample preparation by combining the right sorbent chemistry, device format and methodology. Achieve robust, selective, and sensitive SPE methods without worrying about low recoveries caused by breakthrough of polar compounds, sorbent drying, pH limitations and undesirable silanol activity. Click here to
World’s first system – Fully automated sample preparation module for LC-MS
Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS. The CLAM-2000* (Clinical Laboratory Automated sample preparation Module) automates the pretreatment of blood or other biological samples before LC-MS analysis. It is designed for customers handling blood samples in pharmaceutical departments, medical departments or biological analysis laboratories dealing with
Pass-Through Sample Preparation Product vs. SSLE vs. LLE
Which would you choose? Watch our latest 2 minute Ostro video and get ALL the facts. Watch now
Ascentis® Express Products: Fast HPLC Columns By Sigma-Aldrich
A Breakthrough in HPLC Column Performance Based on Fused-Core® Particle Technology, Ascentis Express HPLC columns offer significant performance benefits over popular columns based on totally porous particles. Ascentis Express columns based on 2.7 μm particles provide the high efficiency separation of sub-2-μm particles, but at higher speed and half of the backpressure. This lower pressure
Thermo Scientific TSQ Vantage
Thermo Scientific* TSQ Vantage triple stage quadrupole mass spectrometer delivers the highest sensitivity with the lowest noise for the quantitative analysis of small molecules, peptides, biosimilars, and biologics. More signal and less noise provides better assay precision and accuracy. Combined with a robust new ion source, second generation (G2) ion optics and hyperbolic quadrupoles, the
New SOLu -Trypsin Enzyme Brings Stability to Mass Spectrometry
Merck’s Advanced Proteomics Grade SOLu-Trypsin is an exclusive, solution stable enzyme for mass spectrometry. Designed to be stable in solution when refrigerated, SOLu-Trypsin can be used immediately without preparation. Other forms of trypsin require thawing or reconstitution, and must be discarded if not used immediately. SOLu-Trypsin allows excess product to be saved for future use, thus eliminating unnecessary waste and cost. SOLu-Trypsin is formulated with a high-purity recombinant trypsin, free of chymotryptic activity, to ensure high fidelity digestion.
ProteinWorks for Large Molecule Quantification…Because Size Matters
Routinely achieve reproducible, accurate, and sensitive protein quantification with ProteinWorks
New Application Note from Waters
Learn how you can reduce processing times and overall cost by using a Simplified Solid Phase Extraction (SPE) 3-step protocol for bioanalysis using Oasis HLB. Get the facts
Nexera UC fully automated SFE-SFC-MS
The Swiss Knife of analytics Shimadzu’s Nexera UC unified chromatography system is the world’s first-ever unified and fully automated instrument combining supercritical fluid extraction (SFE) with supercritical fluid chromatography (SFC). The SFE/SFC/MS platform merges quick and easy online sample preparation with advanced chromatographic analysis and high sensitivity detection. The Nexera UC serves a wide range
Supelco HPLC Accessories
Maximize the performance of your HPLC system View our new HPLC Accessories brochure, which contains a select group of products and recommendations to maximize the performance of your HPLC system. SupelConnect High Performance Fittings Upchurch Scientific Fittings and Accessories Optimize Technologies HPLC Dispersion Measurement PEEK HPLC Fittings Stainless Steel HPLC Fittings Inlet Line Filters Back-Pressure
World’s first system – Fully automated sample preparation module for LC-MS
Shimadzu has released the world’s first system for fully automated sample preparation connected online for LC-MS.
Sample Preparation – Complimentary Applications Notebook
This all encompassing Solid Phase Extraction (SPE) Applications Notebook provides 150 application notes that specifically focus on the pharmaceutical, biopharmaceutical, environmental, food safety and forensic markets. Learn about: The importance of SPE Selection of the correct SPE phase SPE procedure – six steps for a clean extract Solvent selection Method development optimization. Order your free
Bioanalysis Zone Spotlight on Antibody-Drug Conjugates (ADCs)
With the potential to allow targeted delivery of anticancer drugs to tumors, with minimal impact on normal tissue, there is increasing interest in ADCs in new drug development. The heterogeneity and dynamic nature of ADCs raises unique bioanalytical challenges, which Waters explores in Bioanalysis Zone’s Spotlight on ADCs. Learn how these challenges can be addressed
Sample Preparation – Complimentary Troubleshooting Poster
What do you do when you run into sample preparation problems? Hang this complimentary Troubleshooting Poster in your laboratory or office for quick and handy references to fix problems fast. This attractive poster includes solutions to a multitude of Sample Preparation techniques including: Solid Phase Extraction (SPE), Solid-Liquid, QuEChERS, Liquid-Liquid, Modern Soxhlet and Supercritical fluid
Certified Fluka® Pharmaceutical Secondary Standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards. Our secondary standards have multi-traceability to the USP, EP and BP primary standards; in addition, they are manufactured according to ISO/IEC 17025 and ISO Guide 34. The FDA, USP and
Peptides and proteins are not small molecules. Why treat them the same?
Improved microfluidics for better sensitivity and reduced sample load Large molecule quantification is one of the greatest challenges that bioanalysts face. Sensitivity and specificity issues are numerous: fewer molecules per volume; limited recovery due to complex sample prep; increased fragmentation; and so on. The ionKey/MS™ System integrates UPLC analytical separation directly into the source of
Waters CORTECS 2.7 µm Solid-Core Particle Columns have arrived!
CORTECS® 2.7 µm Columns are designed to heighten performance of existing LC system and maximize efficiency at HPLC-optimized backpressures. This pressure advantage without an efficiency trade off, provides the flexibility to run methods using longer column lengths for improved resolution or higher flow rates to speed analysis and increase throughput. Find out more click here
Thermo Scientific™ WebSeal™ system
The Thermo Scientific™ WebSeal™ system presents a range of well plates which meet the requirements of today´s chromatographer using well plate compatible autosamplers. The WebSeal system is a comprehensive range of polypropylene well plates and seals that can be used for different types of analytical challenges and various chromatographic applications. For more information click
Custom Anti-Idiotypic Antibody Generation Service
Custom made anti-idiotypic antibodies are ideal for early and late stage development of therapeutic antibodies, providing high specificity and high sensitivity reagents for PK and ADA assays. Our antibodies are made using the HuCAL® recombinant monoclonal antibody library and a novel and improved method of antibody phage display to generate antibodies in Fab and full
Phenomenex Product Guide 2014/ 2015
Phenomenex Releases Updated Product Guide for 2014/2015 in Print and Digital Formats Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, announces the publication of its updated product and services guide for 2014/2015. Covering the company’s comprehensive lines of HPLC/UHPLC Columns, GC Columns, and SFC columns and
Sciex: SelexION® differential mobility spectrometry
The SCIEX SelexION differential mobility spectrometry (DMS) device delivers highly-selective, robust and powerful ion separation that significantly enhances your quantitative performance. Designed to be simple to install without the need to break vacuum on your MS, and compatible with UHPLC timescales, this separation device can help you address your biggest analytical challenges
Sample preparation guide to fixing problems
Hang this complimentary Troubleshooting Poster in your laboratory or office for quick and handy references to fix problems fast. This attractive poster includes solutions to a multitude of Sample Preparation techniques including: Solid Phase Extraction (SPE), Solid-Liquid, QuEChERS, Liquid-Liquid, Modern Soxhlet and Supercritical fluid extraction.
SILu™MAb Infliximab(MSQC9) is a recombinant, stable isotope-labeled, monoclonal antibody which incorporates [13C6, 15N4]-Arginine and [13C6, 15N2]-Lysine. Expressed in CHO cells, it is designed to be used as an internal standard for the quantitative mass spectrometry analysis of Infliximab in human serum. Infliximab is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor
Thermo Scientific TSQ Module
Current bioanalytical LC-MS/MS workflows require the use of multiple software packages to track samples, acquire and process data, create reports and archive studies. Until now, no LIMS managed the bioanalytical workflow from beginning to end. With Watson LIMS and the TSQ Module working together, data from the entire bioanalytical workflow can reside in a single
Using Tof MRM, Target Enhancement and Ion Mobility for Quantitation using a Time-of-Flight Mass Spectrometer
Poster illustrates benefits of Tof-MRM. Scenarios extend full scan HRMS approaches. Key conclusions: · Additional 2-5 fold sensitivity increase for small molecule drugs in plasma · Simplifies analysis for assays with maximum sensitivity quantitative end points · Traveling wave ion mobility with dynamic range enhancement is currently in development to provide additional quantitative capabilities Download
Anti-hIgG Fc antibodies for generic PK assays
Bio-Rad offers two antibody clones specific to human IgG Fc that can be used to detect human or humanized therapeutic antibodies in non-human primate samples.
Microflow LC/MS for bioanalysis
With ionKey/MS, Waters transforms what your laboratory can accomplish ionKey/MS Systems integrate a UPLC separation into the source of the mass spectrometer, delivering both ease-of-use and best-in-class anlaytical performance. Download our applications compendium to review real-world work performed by Waters scientists that demonstrate the benefits of using the ionKey/MS System and its iKey Separation
Orthogonal choice to RPLC in bioanalysis – Waters
UltraPerformance Convergence Chromatography (UPC2) offers an orthogonal choice to reversed phase liquid chromatography (RPLC) in DMPK applications, particularly in quantitative assays for bioanalysis. Also well-suited for solvents used in sample preparation, UPC2 is compatible with solvents used for sample preparation, eliminating the need for evaporation and reconstitution typically needed for RPLC. For more information click
Thermo Scientific SOLA SPE cartridges and plates – Technical Guide
SOLA products provide unparalleled performance characteristics compared to conventional SPE, phospholipid removal and protein precipitation products. This includes: • Higher levels of reproducibility • Higher levels of extract cleanliness • Reduced solvent requirements • Increased sensitivity. The manufacturing process has the additional benefit of removing extractables from component parts, resulting in cleaner sample extracts. SOLA
Thermo Scientific SOLA – New WCX & WAX Phases for Bioanalysis
The mixed mode weak cation (WCX) and mixed mode weak anion (WAX) phases complement existing selectivity options by providing solutions to an even wider range of application areas. SOLA’s unique design allows for unparalleled performance characteristics and provides increased confidence in results when first time success within the bioanalytical and clinical research workflow is critical.
Prominence Inert LC System
Prominence Inert LC system, a metal-free instrument ideal for analyzing aggregates or other biological macromolecules in biopharmaceuticals.
Sigma-Aldrich: Phytopharma Standards
For the quality control of herbal medicinal products, reliable analytical standards are needed. Sigma-Aldrich offers an extensive range of analytical standards as well as several primary standards (qualified by quantitative NMR). For more information click here.
Nexera XR – tried and trusted all-rounder
Nexera XR – tried and trusted all-rounder A true multi-talent, the Nexera XR ultra high performance liquid chromatograph has become an indispensable tool in laboratories of versatile industries, such as pharmaceuticals, biochemistry, chemistry, environmental and foods. Users benefit from high-speed, high-resolution analysis without compromising robustness or reliability. The Nexera XR modular UHPLC system bridges the