Fast chromatography in the regulated bioanalytical environment: sub-2-µm versus fused-core particles

“Ultimately, column chemistry will play an equal if not more important role than particle size in determining the success/failure of a bioanalytical separation.” Several companies have recently experienced, or will soon experience, patent expirations that will hurt profits and are looking for faster and cheaper ways to develop their pipelines to compensate for the lost revenue. Regulated bioanalytical laboratories are being challenged to increase efficiency and report toxicokinetics and pharmacokinetics concentration results with unprecedented turnaround times. Fortunately, the development of more powerful hardware, software and consumables has made this possible. Higher sensitivity MS systems with faster scan times and UHPLC...

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